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发表于 2002-4-11 16:08
Hepatitis B Therapies Chart
Compiled by Ronald Baker, PhD
Drug Name Drug Class Company FDA Status
Intron A
(interferon alfa-2b) interferon Schering-Plough FDA-approved
Epivir-HBV
(lamivudine; 3TC) nucleoside
analogue GlaxoSmithKline FDA-approved
Adefovir dipivoxil nucleoside analogue Gilead Sciences Phase III *
NDA filed March 2002
Coviracil
(emtricitabine; FTC) nucleoside analogue Triangle Pharmaceuticals Phase III
NDA filing expected in 2002
Entecavir nucleoside analogue Bristol-Myers Squibb Phase III
Clevudine
(L-FMAU) nucleoside analogue Triangle Pharmaceuticals Phase II
ACH 126, 443
(L-Fd4C) nucleoside analogue Achillion Pharmaceuticals Phase II
AM 365 nucleoside analogue Amrad Phase II
(Asia and Australia)
DAPD nucleoside analogue Triangle Pharmaceuticals Phase II
LdT nucleoside analogue Novirio Phase II
XTL 001 monoclonal antibody XTL Biopharm Phase II
(Israel)
Theradigm Immune stimulant Epimmune Phase II
Zadaxin**
(thymosin) Immune stimulant SciClone Phase II
with Epivir-HBV
EHT 899 viral protein Enzo Biochem Phase II
(Israel)
LdC nucleoside analogue Novirio Phase I
HBV DNA vaccine Immune stimulant PowderJect (UK) Phase I
MCC 478 nucleoside analogue Eli Lilly Phase I
(Germany)
ICN 2001 nucleoside analogue ICN Preclinical
Fluro L and D nucleosides nucleoside analogue Pharmasset Preclinical
Racivir nucleoside analogue Pharmasset Preclinical
Robustaflavone nucleoside analogue Advanced Life Sciences Preclinical
Post Exposure and/or Post Liver Transplant Therapies
BayHepB HBV immuneglobulin Bayer (US) FDA-approved
anti-hepatitis B HBV immuneglobulin Cangene (Canada) NDA submitted 2001
Nabi-HB HBV immuneglobulin Nabi FDA-approved
*Adefovir dipivoxil: now available to patients with lamivudine-resistant HBV through an Expanded Access Program. Physicians may call 1-800-GILEAD-5 or 1-650-574-3000.
**Zadaxin: orphan drug approval in US
Sources:
Mark Nelson, MD. Selected Highlights from Drug Development for Antiretroviral Therapies 2001 (Hep DART 2001) December 16-20, 2001, Maui, Hawaii.
New Medicines in Development. Pharmaceutical Research and Manufacturers
[ 此消息由 liver411 在 2002-04-11.03:09:35 编辑过 ] |
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