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发表于 2002-4-28 23:47
Wild-type and` a 'epitope variants in chronic hepatitis B virus carriers positive for hepatitis B surface antigen and antibody
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Date: Sat, 20 Apr 2002 09:42:05 -0400
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Journal of Gastroenterology and Hepatology
Volume 17 Issue 2 Page 148 - February 2002
CHRONIC HEPATITIS B AND C
Wild-type and` a epitope variants in chronic hepatitis B virus
carriers positive for hepatitis B surface antigen and antibody
STEVEN J MESENAS*, WAN C CHOW*, YI ZHAO, GEK K LIM, CHONG J OON AND HAN S NG*
ABSTRACT
AIMS
This study aims to examine the genomic variants of the 'a' epitope in
chronic hepatitis B virus (HBV) carriers positive for both hepatitis B
surface antigen (HBsAg) and antibody to HBsAg (anti-HBs).
METHODS
Eighteen HBV carriers were studied. Hepatitis B virus (HBV) DNA was
extracted and the 'a' epitope region was amplified and sequenced.
RESULTS
Eighteen Chinese asymptomatic HBV carriers were studied. There were 13 patients who were positive for both HBsAg and anti-HBs. Of these, one patient had only wild-type HBV, three had a viral mixture, and five had only 'a' epitope variant HBV. Of the three patients with a viral mixture, all had variants in the less conserved region (123-137). Of the five patients with pure HBsAg mutants, three had variants in the less conserved region while two had variants in the highly conserved region. In this study with a limited number of patients, the serum alanine aminotransferase (ALT) levels were higher in patients with wild-type HBV, compared with those with either 'a' epitope variants or a viral mixture consisting of wild type and variants.
CONCLUSION
Eight of the nine (89) patients positive for both HBsAg and anti-HBs
harbored an 'a' epitope variant. The lower ALT levels seen in patients who had either pure 'a' epitope variant or a mixture of wild type and mutants suggest that a closer monitoring of these 'a' epitope variants should be required, as patients carrying these infectious viral strains may remain asymptomatic.
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