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发表于 2002-4-28 23:57
Subtype-dependent response of hepatitis B virus during the early phase of lamivudine treatment
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Date: Thu, 18 Apr 2002 04:38:27 -0400
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Clin Infect Dis 2002 May 1;34(9):1273-7
Subtype-dependent response of hepatitis B virus during the early phase oflamivudine treatment.
Zollner B, Petersen J, Schafer P, Schroter M, Laufs R, Sterneck M, Feucht HH Institute for Medical Microbiology and Immunology, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany. [email protected]
We conducted a 12-month longitudinal investigation of the subtype-dependent response of hepatitis B virus (HBV) to lamivudine treatment in 43 consecutive patients with chronic hepatitis B. HBV subtype ayw appears to respond better to lamivudine monotherapy than does HBV subtype adw (P=.005).
This might be the reason for the lower incidence of lamivudine-resistant strains observed in persons infected with HBV subtype ayw during follow-up.
Publication Types:
a.. Clinical trial
b.. Controlled clinical trial
PMID: 11941556, UI: 21937968
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