HBV Vertical Transmission...despite 3T therapy

liver411

MAY  2002

VIRAL HEPATITIS B-Vertical transmission of hepatitis B virus despite maternal lamivudine therapy



S.N Kazim (1,2), S. M Wakil (1), L. A Khan (2), S. E Hasnain (3), S. K Sarin (1)



(1) Department of Gastroenterology, (2)Department of Biosciences, Jamia Millia Islamia, New Delhi;

(3) Eukaryotic Gene Expression Laboratory, National Institute of Immunology, New Delh



Lamivudine given during the last weeks of pregnancy in women with chronic hepatitis B has been reported to be safe. We report a case of chronic hepatitis B virus (HBV) infection in a newborn, despite suppression of HBV DNA to undetectable levels in the mother by prolonged lamivudine therapy. The newborn had raised alanine aminotransferase concentrations and was positive for HBV DNA at birth which persisted until 9 months of age, despite neonatal vaccination, treatment with hepatitis B immune globulin, and high concentrations of anti-HBs. On HBV DNA sequencing, complete sequence homology and a similar precore mutation was found in the mother and child, indicating vertical transmission. Lamivudine therapy might not prevent perinatal transmission of HBV infection in every newborn. (Lancet, 359: 1488-89, 2002)