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肝胆相照论坛 论坛 学术讨论& HBV English 慢性患者:HBV诱导细胞自亡
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慢性患者:HBV诱导细胞自亡 [复制链接]

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发表于 2009-6-13 21:20 |只看该作者 |倒序浏览 |打印

Hepatitis B virus triggers cell 'suicide' in patients with chronic infection


Scientists from UCL (University College London) have identified a key difference between people who can fight the Hepatitis B virus (HBV) off successfully and those who fail to do so – that a group of cells important in controlling the disease are triggered to ‘commit suicide’ in patients who are chronically infected. This discovery provides an important new focus for developing therapies or vaccines that boost the body’s ability to manage this infection.

The researchers analysed thousands of genes in T cells, critical players of the immune system required for control of HBV. They found that T cells from patients who were chronically infected were triggered to ‘commit suicide’. This could be an important factor in determining why these patients’ immune systems cannot fight the infection, and a process which could be a useful target for new treatments. Their findings are published today in the Journal of Clinical Investigation.

Hepatitis B virus (HBV) is one of the most common viruses in the world, and ranks as one of the top ten killer infectious diseases. More than 350 million people have long-term infection with HBV, which may lead to liver cirrhosis, liver failure or liver cancer. In the majority of adults infected, the immune system is able to control the virus very well and is, in fact, more effective than any currently available treatment. Understanding what goes wrong in people with chronic infection is crucial to the development of new therapies.

Lead author, Dr Mala Maini, UCL Division of Infection & Immunity, said: “We used microarray gene chips to screen more than 5,000 genes in T cells from both recovered and chronically infected Hepatitis B patients. This led to the discovery that, instead of successfully reacting to the virus, the T cells in the latter group were triggered to commit suicide by one of the cells’ own death-inducing proteins, called ‘Bim’. We are now looking into the fine mechanism driving this outcome.”

The paper’s first author, Ross Lopes, added: “If we can develop safe ways of blocking the suicidal tendency of the T cells, we may be able to prolong their survival, so they can do a better job of controlling Hepatitis B infection.”

The proportion of the world's population currently infected with HBV is estimated at between 3 and 6 per cent, but up to a third have been exposed. It is endemic in parts of Asia and Africa. Chronic Hepatitis B may eventually cause liver cirrhosis and liver cancer, a fatal disease with very poor response to current treatments. The infection is preventable by vaccination at a young age.

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发表于 2009-6-13 22:24 |只看该作者
真的看不明白  ,  拜托高人翻一下吧  。

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荣誉之星

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发表于 2009-6-14 00:09 |只看该作者
大致意思是,病毒造成T细胞死亡,从而无法控制感染。
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这可能可以用来解释硬化的原因。
我是希尔瑞斯。

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发表于 2009-8-13 21:53 |只看该作者
They found that T cells from patients who were chronically infected were triggered to ‘commit suicide’. This could be an important factor in determining why these patients’ immune systems cannot fight the infectiion
楼上正解,but the jsut using gene chips to detet the different betwen two kinds of cell. It dont mean anything ,just a shit of paper.

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发表于 2009-9-11 10:51 |只看该作者
大意是:
UCL的科学家发现,人群感染HBV后,有一种人的自身免疫系统可以成功地抵抗病毒,而另一种人却不行。这两种人的关键区别在于,后者的T细胞会被诱导“自杀”。他们发现在后者的T细胞里有一种叫做"brim"的诱死蛋白质,这导致了T细胞的自杀。如果能够安全地阻断T细胞的自杀倾向,从而延长它的寿命,将有助于后者更好地抵抗病毒。
另外,他们提到大部分的感染者可以自愈,比目前有的任何疗效都有效,所以应该去研究那些不能成功抵抗病毒的感染者到底是哪里出错了。

如有译错的地方,欢迎指正。
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