HBV及HCV感染时的肝癌监测

帅庭

文章导读：在APSAL大会的第二天，Kwang-Hyub Han教授做了题为Recommendation on the Surveillance Program for HBV and HCV的大会报告。
HCC Surveillance for HBV and HCV
Kwang-Hyub Han
Yonsei University College of Medicine, Seoul, Korea

On the second day of APASL, Professor Kwang-Hyub Han gave a lecture on hepatocellular carcinoma (HCC) surveillance for patients with HBV and HCV infection. He said increasing evidences suggested that persistent HBV replication indicated as serum HBV DNA concentration was a predictor of HCC. Therefore, suppression of HBV replication by oral nucleotide analogue resulted in lower incidence of HCC.

    On the other hand, in patients with chronic hepatitis C, the incidence of HCC in cirrhotic patients is 2-8% per year, significantly higher than that in non-cirrhotic patients. Since advanced hepatic fibrosis is more correlated with HCC development, simple and non-invasive assessment of liver fibrosis is more important in surveillance, and a large scale study on these non-invasive methods is necessary.

At last, Professor Kwang-Hyub Han recommended that US and serum AFP measurement every 6 months shoud be the most appropriate method in the surveillance of HCC. However, because of the low sensitivity, alternative method or identification of a novel biomarker may be required
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