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Patients with chronically inactive liver disease (HBsAg inactive carriers) showed minimal proliferative capacity against HBc and HBc-derived peptides, while they retained a relatively increased pool of effector T cells. Within this population, an expanded subset of envelope specific cells was present. Maini et al. [26] have recently shown using MHC-Itetramers, that HBsAg inactive carriers, maintain a number of functional CD8+ T lymphocytes in the hepatic parenchyma and the periphery. Although, in our study the functional characteristics of these T cells was not investigated, we can speculate that in HBsAg inactive carriers, a dynamic population of HBV specific T cells, both in the liver and periphery exists, that is able to produce antiviral cytokines (i.e. IFN-gama) and thus suppress HBV replication without cytolytic liver damage.
对于慢性非活动性乙肝(HBsAg阳性的携带者),免疫系统针对HBc(乙肝病毒核心蛋白)和源自HBc的缩氨酸的增生能力最低,但是效应T细胞池相对比较大。在这个效应T细胞池中,有针对病毒鞘蛋白的特异细胞存在。Maini在《病毒特异性CD8+细胞在持续性乙肝感染导致的肝损伤和病毒控制中的角色》中认为在非活动性乙肝患者的肝组织和外周中保有一定数量的CD8+ T淋巴细胞。我们虽然没有研究这些细胞的功能特征,但是可以推测:非活动性乙肝病人机体内,有一个具有动态数量的HBV特异性T细胞群,在肝组织和外周都存在,它们能够产生抗病毒因子(比如伽玛干扰素)抑制病毒的复制,同时不造成肝细胞损伤。
[ 本帖最后由 VirusIsNothing 于 2008-12-24 18:43 编辑 ] |
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