Ribavirin可能可以帮助entecavir辅助治疗

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Ribavirin可能可以帮助entecavir辅助治疗

这只是很初步的研究结果，仅供相关人士参考，不能用于指导临床！
entecavir也仅是众多核苷类似物中普普通通一员。

Ribavirin在HCV治疗中是用于辅助PEG-Interferon.

从原理上来说：entecavir是基于guanine碱基类似物，而Ribavirin是IMP-dehydrogenase的抑制剂，
可以降低细胞内dGTP载量。

Ribavirin是否可用于entecavir辅助治疗HBV，有待进一步研究。

Source, PubMed

Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir.

Antiviral Res. 2007 Mar;73(3):192-6

Authors: Ying C, Colonno R, De Clercq E, Neyts J

MPA [the active metabolite of the immuno-suppressive agent CellCept] and ribavirin markedly potentiate the anti-HBV activity of the guanine-based nucleoside analogue entecavir (ETV) against both wild-type HBV and a lamivudine-resistant variant. Ribavirin (in its 5'-monophosphate form) and MPA are inhibitors of IMP-dehydrogenase and cause depletion of intracellular dGTP pools. The active triphosphorylated form of ETV may inhibit more efficiently the priming reaction, reverse transcription and DNA-dependent DNA polymerase activity of the HBV polymerase in the presence of reduced levels of dGTP. The potential for enhanced ETV activity is supported by the observation that exogenously added deoxyguanosine reversed the potentiating effect of ribavirin and MPA. Our observations may have important implications for those (liver) transplant recipients that receive MMF as part of their immunosuppressive regimen and who, because of a de novo or a persistent infection with HBV need antiviral therapy such as ETV. Further studies will need to be conducted to determine if combining ribavirin (a compound used for the treatment of HCV infections) with ETV could have an advantage for the treatment of HBV infections, in particular in patients co-infected with HCV.

IC

利巴韦林+长效干扰素是HCV首选方案．

利巴韦林价格低，广谱抗病毒，可是用在HBV上没什么效果，加上还有副作用．