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Re:维生素B1(硫胺素)具有清除乙肝病毒的作用
资料转贴
中级站友 发表于 2001-10-06.14:53:06
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VE大概好一点,对了,VC的评论好坏不一,我通常感冒时用VC
有两种维生素被认为有好处:VB1 和 V E
A
前一段有朋友提到过维生素B1有好处
我也鼓吹, 这些都是根据国外的一篇报道
后来我看了报道的原文, 了解到维生素B1并没有那么好的作用。
作者大概是美国的一名军医,他对他的3个病人服用维生素B1进行了观察。
结论是维生素B1有一定好处。
我认为参考价值并不大:
1 病人只有3个
2,这3个病人年龄都大于40,男性,都是成年感染(作者猜测是越战时感染)
B另一种是维生素E
我只看到一篇报道, 这种情况也不是太可信
姑且把作者的摘要放在这里(我没有看到原文)
作者是意大利的
发表在 抗病毒研究杂志(名气不响)2001年2月份的
摘要主要说:
维生素E可能(might)可以提高免疫力
32病人;15个用维生素E,300毫克/次, 2次/天,用3个月, 另外17个为对照(不吃药)
吃完后结果:
用维生素E的 ,有7个转氨酶正常,7/15 ,有8个hbv dna转阴,8/15;
不用的, 转氨酶(alt)只有1个正常1/17,有3个hbv dna转阴3/17;
作者结论: 维生素E 可能有用。
Antiviral Res 2001 Feb;49(2):75-81
Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial.
Andreone P, Fiorino S, Cursaro C, Gramenzi A, Margotti M, Di Giammarino L, Biselli M, Miniero R, Gasbarrini G, Bernardi M
Semeiotica Medica, Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Universita di Bologna, Policlinico Sant'Orsola, Via Massarenti, 9, 40138, Bologna, Italy. [email protected]
BACKGROUND AND AIMS: Interferon-alpha treatment has been the treatment of choice for chronic hepatitis with unpredictable results. Recently, Lamivudine has been licensed for use against HBV infection with good results. Unfortunately, recurrence of viremia after lamivudine withdrawal is common and prolonged treatment can induce the emergence of resistant mutant strains. It has been shown that vitamin E can increase the host immune response, and this may provide protection against infectious diseases. METHODS: We evaluated vitamin E supplementation as therapy for chronic hepatitis B in a pilot study including 32 patients. Patients were randomly allocated to receive vitamin E at the dose of 300 mg twice daily for 3 months (15 patients) or no treatment (17 patients). They were seen monthly during the first 3 months and thereafter quarterly for additional 12 months. RESULTS: The two groups were comparable at enrollment. At the end of the study period, alanine aminotransferase (ALT) normalization was observed in 7 (47%) patients in vitamin E group and only in 1 (6%) of the controls (P=0.011); HBV-DNA negativization was observed in 8 (53%) patients in the vitamin E group as compared to 3 (18%) in the control group, respectively (P=0.039). A complete response (normal ALT and negative HBV-DNA) was obtained in 7 (47%) patients taking vitamin E and in none of the controls (P=0.0019). CONCLUSION: Vitamin E supplementation might be effective in the treatment of chronic hepatitis B.
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