什么是乳酸脱氢酶（LDH：Lactic Dehydrogenase ）？

liver411

什么是乳酸脱氢酶（LDH：Lactic Dehydrogenase ）？



有时肝脏科医生要给肝病患者测定LDH．



LDH-乳酸脱氢酶是糖酵解过程中一种重要的酶，任何原因引起的肝细胞损伤均可因LDH逸出，引起血清LDH活力增加．急性肝炎或慢性肝炎活动期LDH常显著或中度增加，其临床意义大致与ALT、AST一致，但有人认为LDH反映肝细胞损害的灵敏度略逊于ALT．从发病到肝炎恢复期，LDH为最早恢复的酶．如果在疾病后期，病人未进行剧烈体力活动而LDH进行性升高或反复波动，常提示有某种并发症存在．故反复，定期，固定测定LDH有助于观察病情．特别是肿瘤组织中糖酵解速度明显高于正常组织，故肝癌时血清LDH活力明显升高．在肝硬化患者，如在病程中发现LDH增加，应疑及并发肝癌，再结合AFP，图像，穿刺可以早期判断病变．



但是血清LDH测定对肝病缺乏特异性，当含有LDH的心肌、肾、血细胞和肠等组织损伤时，LDH也会升高，如见于心肌梗塞、肺梗塞、进行性肌营养不良、肌炎、溶血性贫血、恶性贫血、白血病、肝以外恶性肿瘤等，这时结合其它指标可排除／考虑病因．



参考：



Lactate dehydrogenase (LD or "LDH")

Increase of LD activity in serum may occur in any injury that causes loss of cell cytoplasm. More specific information can be obtained by LD isoenzyme studies. Also, elevation of serum LD is observed due to in vivo effects of　anesthetic agents, clofibrate, dicumarol, ethanol, fluorides, imipramine, methotrexate, mithramycin, narcotic analgesics, nitrofurantoin, propoxyphene, quinidine, and sulfonamides.



Decrease of serum LD is probably not clinically significant.



There are two main analytical methods for measuring LD: pyruvate->lactate and lactate->pyruvate. Assay conditions (particularly temperature) vary among labs. The reference range for the assaying laboratory must be carefully studied when interpreting any individual result.



Hugs,

Sheree



----- Original Message -----

From: <[email protected]>

To: <[email protected]>

Cc: <[email protected]>; <[email protected]>

Sent: Tuesday, March 19, 2002 10:14 PM

Subject: [HB] LDH









Hi Pam,



Do you know what is the purpose of the LDH result?



Deena









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