The point was demonstrated further by using explanted organ cultures in which human testis tissue was grown in culture. This testis culture, which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture.
通过对人睾丸组织培养进一步证实了这点，这些培养的细胞和活体中一样分泌睾丸激素，能被HIV－1病毒感染，培养物中的病毒和体内收集的病毒都能感染容许性细胞。
The finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological sanctuary梞any anti-retroviral drugs have difficulty penetrating this organ and may be present at sub-therapeutic levels. Thus, although HAART may achieve undetectable virus levels in the blood, virus replication in the testis may permit continued spread of the virus.
这一发现意义重大，因为睾丸很难用药，抗逆转滤过性病毒药物无法穿过组织生效，使其处在亚治疗状态，因此，即使HAART疗法可以除去血液中的病毒，但是残留在睾丸中的病毒还是会使病毒继续传播。
Finally, with HIV infection continuing to rise, the development of anti-retroviral therapy that effectively targets all sources of HIV, including the testis, is gravely needed. The use of this testis culture system may allow assessment of new anti-retroviral drugs that target HIV in the testis.
随着HIV感染人群的继续增多，亟需开发抗逆转滤过性病毒疗法，指向所有传播途径包括睾丸中的HIV病毒，这个睾丸培养物系统的使用有助于对新药的估价。 http://www.dxy.cn/bbs/post/view?bid=116&id=7629297 | 
发表于 2007-1-23 16:57
