缺乏ETV和LAM,ADV,Viread联用的药物动力学数据(2005.4.23)

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Lack of a Pharmacokinetic Interaction When Entecavir Is Coadministered with Lamivudine, Adefovir or Tenofovir?br>

Pharmacokinetic (PK) parameters of ETV, LVD, ADV and tenofovir/ TDF (Viread) given alone and in combination are shown in the?table below. There was no effect of co-administration of LVD, ADV, or TDF on ETV pharmacokinetics. Similarly, ETV had no effect on the pharmacokinetics of?LVD, ADV, or TDF. For all combinations tested, the adjusted geometric means for AUC(TAU), Cmax, and Cmin of each drug when co-administered were similar to those values for the drug alone: in every case, the corresponding 90% C.I.s satisfied the pre-specified criteria (0.80-1.25) for lack of effect.?

ETV may be co-administered with LVD, ADV, or TDF without dose modification of either ETV or the co-administered drug.

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Reference M Bifano and others. Abstract 473. 40th EASL. April 13-17, 2005. Paris, France.