携带HBVDNA的HBV儿童进行Alpha IFN治疗后发生S抗原转换的原因

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J Hepatol. 2005 Apr;42(4):486-90. Epub 2005 Jan 13.

Persistence of HBV-DNA in children with chronic hepatitis B who
seroconverted to anti-HBs antibodies after interferon-alpha therapy:
correlation with specific IgG subclass responses to HBsAg.

Gregorek H, Dzierzanowska-Fangrat K, Woynarowski M, Jozwiak P,
Witkowska-Vogtt E, Socha J, Syczewska M, Madalinski K.

Department of Microbiology and Clinical Immunology, The Children's Memorial
Health Institute, 04 730 Warsaw, Poland.

BACKGROUND/AIMS: We examined the persistence of HBV-DNA in sera collected
4-10 years after IFN-alpha therapy from patients with chronic hepatitis B
who had seroconverted to anti-HBs antibodies. We also wanted to assess
whether any association exists between HBV-DNA status and the IgG anti-HBs
subclass responses. METHODS: Sera were obtained from 38 patients and the
following parameters were determined in each of them: (1) serological
markers of HBV; (2) concentrations of IgM, IgG, IgA; (3) total IgG
subclasses. HBV-DNA and IgG anti-HBs subclasses were determined in anti-HBs
positive sera. RESULTS: Four to 10 years after therapy, anti-HBs were found
in 37 of 38 patients (GMT: 775IU/L). In 13 of them (35.1%) free and/or bound
HBV-DNA was present in sera. Significant differences in the profiles of IgG
anti-HBs were observed when the HBV-DNA status was considered. Patients with
undetectable HBV-DNA responded mainly with IgG1 and/or IgG3, while in the
HBV-DNA-positive group, a high contribution of IgG4 was found. CONCLUSIONS:
Our study showed that HBV-DNA may persist for a long time after IFN-alpha
therapy despite the appearance of anti-HBs antibodies. The monitoring of
specific IgG subclasses may be of predictive value for HBV-DNA persistence.

PMID: 15763334

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correlation with specific IgG subclass responses to HBsAg

试翻译为:和免疫球蛋白IgG对HBsAg的反应低下有关

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