长期拉米治疗给HBV患者带来良好的效果(2005.3.16 日本东京Toranomon医院肝病科)

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Long-term Lamivudine Therapy Shows Favorable Efficacy in Patients with Chronic Hepatitis B ?

The long-term efficacy of lamivudine (Epivir-HBV) therapy in patients with hepatitis B virus (HBV) infection is still not clear. In this study, 20 non-cirrhotic Japanese patients infected with HBV received lamivudine therapy for more than 1 year and were followed for a median period of 8.5 years.

The rates of HBe antigen (HBeAg) negative, HBV-DNA undetectable, and alanine aminotransferase (ALT) normal level at the start of lamivudine were 55%, 25%, and 20% and 85%, 80%, and were 80%, respectively, at the last visit, including patients who received additional treatment.

Findings

The values at the last visit tended to and were significantly higher than those at the start. The values improved at the last visit regardless of the emergence of YMDD motif mutant and continuation of lamivudine.

YMDD mutant and biochemical relapse with mutant virus (breakthrough hepatitis) appeared in 65% and 45% during follow-up, respectively, but severe breakthrough hepatitis occurred in only 5%. Furthermore, 80% of patients who received additional treatment for breakthrough hepatitis, regardless of continuation of lamivudine, were ALT normal level at the last visit, in contrast to 25% untreated.

HBsAg clearance occurred in two patients of the discontinuous lamivudine group with non-vertical transmission, who were relatively young. One was infected with HBV genotype C with breakthrough hepatitis and the other had no YMDD mutant and was infected with genotype D, a rare type in Japan.

None developed cirrhosis or hepatocellular carcinoma (HCC) during follow-up.

In conclusion, the authors write, "Our results suggest that long-term lamivudine therapy improves long-term prognosis, especially when additional treatment for breakthrough hepatitis is used."

Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan. 03/16/05

Reference N Akuta and others. Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: An 8-year follow-up study. Journal of Medical Virology 75(4): 491-498. April 2005.