接受拉米夫定治疗的中国慢性乙型肝炎病毒感染患者的HBsAg 血清清除

tonychant

前言 这是我国香港大学学者在2004年第10期Journal of Clinical Microbiology杂志上发表的一篇英文文献,报道了在香港的中国患者接受拉米夫定治疗发现可导致HBsAg 血清清除. 在2004年的Journal of Gastroenterology and Hepatology (2004 19, 958–969)的一篇题为"Practical difficulties in the management of hepatitis B in theAsia–Pacific region"的亚太意见上,总结了亚太地区HBV的感染状况, 发现中国大陆HBV感染人群为9.7%,而香港为8.8%; 在HBsAg阳性人群中伴有HBeAg阳性者中国大陆占40--50%,而香港为60%; HBV基因型中国大陆A型1.37%,B型17.27%,C型81.36%,而香港B型20--25%,C型75--80%, 上述资料初步表明在中国大陆与香港HBV的感染的类型和状况相似,对于香港的临床资料在大陆可能有很大的参考价值. 文题：HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection. 作者：Yuen MF, Wong DK, Yuan HJ, Sum SM, Lai CL. 杂志全名：Journal of Clinical Microbiology 年份，卷（期）: 起止页码：2004 ;42(10):4882-4. PMID:15472371 英文摘要： We report two Chinese patients in whom lamivudine treatment resulted in HBsAg seroclearance. One patient received lamivudine, and another patient received 12-week famciclovir treatment followed by lamivudine. Lamivudine was maintained after HBeAg seroconversion. These two patients lost HBsAg at 24 and 27 months (ages, 23 and 19.3 years, respectively) and developed measurable titer of anti-HBs after 65 and 71 months of therapy, respectively. The liver biochemistry was normal after HBeAg seroconversion. The serum hepatitis B virus (HBV) DNA levels were undetectable (<200 copies/ml) both at the time of HBeAg seroconversion and at the last follow-up. Liver biopsy of one patient showed nearly normal histology, with undetectable intrahepatic total HBV DNA and covalently closed circular DNA. In conclusion, lamivudine therapy can result in HBsAg seroclearance at an early age even though the phenomenon is rare. 中文译文：接受拉米夫定治疗的中国慢性乙型肝炎病毒感染患者的HBsAg 血清清除 [摘要] 我们报道两例拉米夫定治疗导致HBsAg 血清清除的中国患者，一例接受拉米夫定治疗,另一例接受12周泛昔洛韦后行拉米夫定治疗,在HBeAg血清转换后维持拉米夫定治疗,两例患者分别在24个月与27个月HBsAg阴转(年龄分别23岁与19.3岁),在治疗后分别65个月与71个月出现可测定滴定量的抗HBs抗体,HBeAg血清转换后肝生化恢复正常,在HBeAg血清转换时与随访末血清HBV DNA水平无法检测(<200拷贝/ml ),一例患者的肝活检显示接近正常,肝内总HBV DNA与cccDNA无法检测,结论;在年轻患者拉米夫定治疗可以导致HBsAg 血清清除,虽然这一现象较为罕见.

[此贴子已经被作者于2004-11-19 19:55:00编辑过]

jackwen

少见

我不怕死

一楼说的是不是表明那两位是不是完全的治好了.

flyinduck

并不一定是药物治好的，自然阴转也差不多是这个比例