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3楼
发表于 2004-9-17 23:43
3 多聚酶结构域与抗病毒治疗
全球有3亿以上人口成为HBV的慢性携带者,HBV感染是一个严重的公共健康问
题. 慢性HBV携带的最大危害是发展为肝硬化和肝癌[13,20-25]. 核苷类似物如拉
米夫定等是目前效果较好的抗病毒治疗制剂,但长期抗病毒治疗(大于6 mo)可引起
病毒变异,病情反复,甚至病情急剧加重,导致死亡[26-29]. 最常见的病毒变异
为多聚酶结构域的(YMDD)的第204位蛋氨酸被异亮氨酸取代(M204I)(ATG→ATT)成为
YIDD,或蛋氨酸被缬氨酸取代(M204V)成为YVDD [4, 26-27],其他病毒变异还有4
26位亮氨酸被异亮氨酸取代(L426I)和550位蛋氨酸被异亮氨酸取代(M550I),以及
L528M, M552V,M552I[28]变异,L526M、M550V、M550I[29]等. 因此,掌握抗病
毒治疗和停药的正确时机,克服病毒变异是提高治疗成功率的关键.
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