Hepatitis A vaccine...

liver411

J Med Virol. 2004 Feb;72(2):194-6.


[B]Hepatitis A vaccine: Indirect evidence of immune memory 12 years after the
primary course.[/B]

Van Herck K, Van Damme P, Lievens M, Stoffel M.

Centre for the Evaluation of Vaccination, University of Antwerp, Belgium.

Vaccine-induced hepatitis A antibodies persist up to 10 years in adults,
with mathematical models estimating further persistence up to 20-25 years.
Thirty-one adults received booster inoculations 12 years after their initial
vaccination (Havrix trade mark 720 El.U at months 0, 1, 6). At the time of
booster inoculation, all still had detectable antibodies. All but one
subject met pre-defined criteria for anamnestic response 14 days after the
booster, and all subjects did so after 30 days. The subjects' geometric mean
titre (GMT) increased rapidly from 242 IU/L at baseline to 3,832 IU/L at day
14 and 5,282 IU/L at day 30. This study shows a substantial immune response
to re-exposure to hepatitis A antigen after 12 years, which occurs rapidly
to ensure protection within the average incubation period of hepatitis A
virus. J. Med. Virol. 72:194-196, 2004. Copyright 2004 Wiley-Liss, Inc.

PMID: 14695659 [PubMed - in process]