持续阳性的HbeAg是原发性肝癌的独立预测因素

清照

2003年03月31日
38th Annual Meeting of the EASL

Persistently Positive HBeAg Is Independent Risk Factor for Hepatocellular Carcinoma

Abstract Summary

Results of previous population-based studies in Taiwan and Alaska suggest positive HBeAg as a risk factor for hepatocellular carcinoma (HCC), but the status of liver cirrhosis among the studied patients was not defined. Researchers at the Department of Medicine at the Chinese University of Hong Kong investigated whether positive HBeAg is an independent risk factor for HCC.

Patients with chronic hepatitis B were prospectively followed up 6-monthly with monitoring of HBeAg status and alfa-fetoprotein levels. HCC was confirmed imaging and/or histology. Liver cirrhosis was defined as ultrasonic cirrhosis plus hypersplenism, ascites and/or varices. A Cox-proportional hazard model was used to estimate the relative risk of HCC development in relationship with age, gender, liver cirrhosis and HBeAg profile.

427 patients (279 male and 148 female) were followed up for a median of 44 months (range 3 to 55). Twenty-one patients developed HCC after follow up for a median of 18) months (range 3 to 43).

The adjusted relative risk (ARR) of HCC was significantly higher among patients who had persistently positive HBeAg (n=89) as compared to patients with persistently negative HBeAg (n=257) (2.80, 95% CI 1.02-7.63).

Fluctuating HBeAg status (n=36) did not associate with increased risk of HCC (ARR 1.6, 95% CI 0.43-5.53). None of the patients who underwent sustained HBeAg seroconversion developed HCC (n=45). Cirrhosis was associated with a high risk of HCC (ARR 7.24, 95% CI 2.91-18.01).

Conclusion

Persistently positive HBeAg in the absence of cirrhosis is an independent risk factor for hepatocarcinogenesis and close surveillance should be offered.

Reference

HLY Chan and others. PERSISTENTLY POSITIVE HEPATITIS B E ANTIGEN ISASSOCIATED WITH INCREASED RISK OF HEPATOCELLULAR CARCINOMA. Abstract 3020.00. Abstracts of the 38th Annual Meeting of the European Association of the Study of the Liver (EASL).

清照

肝癌的调整相对危险性在HBeAg持续阳性的病人中明显较HBeAg持续阴性的病人要高（2.80，95% CI 1.02～7.63）。取得持续HBeAg转换的病人没有1例发生肝癌，肝硬化与肝癌的发生率明显相关。结论：持续阳性的HbeAg是原发性肝癌的独立预测因素。

寒烟翠

那不是很可怕，我是五年前查出大三，肝功一直正常，没吃过药，那我怎么办？？？？

我找到了

可是来自medline?

清照

以下是引用我找到了在2003-12-19 23:52:10的发言：
可是来自medline?

38th Annual Meeting of the EASL