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发表于 2003-11-2 19:33
[B] in a Canadian First Nations community[/B]
CANADIAN JOURNAL OF GASTROENTEROLOGY
October 2003, Volume 17, Number 10 : 593-596
GY Minuk, M Zhang, SGM Wong, et al
Serological markers for hepatitis A (HAV), B (HBV) and C (HCV) were
documented in 315 inhabitants (27%) of a central Manitoba First Nations
community. Serologic evidence of HAV infection (anti-HAV positive) was
almost universal (92%) by the age of 20 years. HBV infection (antibody to
hepatitis B core antigen positive) had occurred in only 2.3% of the study
population and no chronic carriers were identified. Serological evidence of
HCV infection (anti-HCV positive) was documented in 2.2% of the population
but ongoing viremia (HCV-RNA positive by polymerase chain reaction) was
absent. The results of this study highlight the importance of universal HAV
vaccination; likely reflect the efficacy of existing prenatal screening and
immunoprophylaxis programs for HBV; and raise the possibility that First
Nations peoples have an enhanced ability to spontaneously clear HCV.
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