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发表于 2003-8-30 23:53
[B]Are HBV Vaccine Booster Doses Unnecessary in Immunocompetent Persons?[/B]
This review analyses the cumulated data from a number of long-term follow-up studies among infants, children and adults vaccinated against hepatitis B in industrialized and developing countries.
Despite low or undetectable antibody responses years after vaccination, the development of HBsAg was a rarity and, if present, only transient. Some vaccinees developed anti-HBc responses but none developed an HB carrier state or clinical manifestations of disease.
Studies demonstrating anamnestic responses among those with low or undetectable anti-HBs levels following challenge with HB vaccine, together with the production of anti-HBs in circulating B-cells by spot ELISA, confirmed the presence of immune memory among vaccinees.
Anamnestic anti-HBs responses all correlate close in kinetics and magnitude with proliferative T-cell responses.
The accumulated data from studies assessed in this review indicate that protection is dependent on immune memory, rather than declining anti-HBs responses and add additional weight to the European Consensus recommendations that following a complete course of vaccination, booster doses are unnecessary in immunocompetent persons.
If implemented, this recommendation will have considerable cost benefits world-wide.
08/18/03
Reference
JE Banatvala and P Van Damme. Hepatitis B vaccine - do we need boosters? Journal of Viral Hepatitis 10(1): 1-6. January 2003.
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