罗氏：Pegasys能显著促进乙肝治疗

麦克狼

罗氏：Pegasys能显著促进乙肝治疗


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战胜乙肝 http://www.hbver.com 　2003-4-10  来源:基因潮 　 作者:  阅读125次
   

　　瑞士制药巨头罗氏（Roche）4月9日表示研究证明该公司的抗丙肝药物Pegasys能有效促进乙肝的治疗。

SYDNEY -(Dow Jones)- Swiss pharmaceutical company Roche Holding AG said Wednesday a new study found that its hepatitis C drug Pegasys also more than doubled the efficacy of conventional treatments of chronic hepatitis B.

Study results presented April 9 at the 11th International Symposium on Viral Hepatitis and Liver Disease, in Sydney demonstrate that PEGASYS, a new generation hepatitis C therapy, more than doubled the efficacy of conventional interferon in the treatment of chronic hepatitis B (CHB).

The Phase II study assessed the efficacy of PEGASYS in patients with difficult-to-treat HBeAg-positive CHB, which was defined as high pre-treatment HBV DNA (high levels of replicating virus in the patient's liver) and low pre- treatment ALT (indicating a weak natural response from the patients immune system to HBV).

These factors are considered predictors of a poor response to HBV therapy. As in hepatitis C, where genotype 1 is considered difficult to treat, there is also evidence that those infected by the HBV genotype C virus respond less well to treatment.

"Until now, there was only a slim chance that these hepatitis B patients could be cured of their disease," said Professor Graham Cooksley, the lead investigator of the study and Senior Principal Research Fellow, Clinical Research Centre, Royal Brisbane Hospital, Australia.

"These monotherapy results are extremely positive and demonstrate the same kind of efficacy in hepatitis B as we saw with genotype 1 patients in hepatitis C. PEGASYS works very well in those with the most treatment-resistant disease."

Company Web Site: http://www.roche.com

麦克狼

丙肝新药Pegasys获准
2003-1-2 已有573人阅读


　　罗氏药厂(Roche)生产的新药Pegasys已经获准用于治疗慢性丙肝成人患者。这是干扰素α的一种长效剂型，适用于那些肝脏虽然已经损伤但功能还较好、因而没有接受过标准干扰素α治疗的患者。作为这种新药的引进，该药厂将从12月31日起为前15,000例患者提供12周的免费Pegasys。Pegasys的属名为peginterferon alfa-2a，每周注射一次，每次180微克，可连续治疗48周。已经完成的三项临床治疗结果表明该药能有效抑制丙肝病毒：38%的患者在治疗68周后检测不出病毒。但专家们同时也提醒说，由于该药属于干扰素α类，因此仍有可能会产生某些副作用，例如一些神经性、精神病性、自体免疫性以及传染性病症。上述临床治疗中发生最多的副作用包括头痛、疲乏、肌肉痛、发烧、寒战、关节痛、恶心、脱发、注射部位皮肤刺激、白细胞数减少、失眠、抑郁、焦虑和易怒等。  
                                            摘自《新华社》

彻底转阴

2700一针，一周一针。一年需要14万。

[此贴子已经被作者于2003-4-18 13:26:25编辑过]

彻底转阴

这个药物的国内治疗乙肝的临床报告我都大体知道，有效率比干扰素高一些，但是太贵。除了极端有钱的人，一般患者无需关注。

麦克狼

干扰素刚开始也很贵，等国内开始仿制就便宜了。长效干扰素也一样。

jazz_2000

光副作用听了就可怕，哎，乙肝真苦！！

jazz_2000

38%检测不出病毒是DNA还是抗原滴度啊？？？

cfz5

指丙肝病毒RNA.

低科技

Pegasys－－派罗欣。聚乙二醇干扰素（ＰＥＧ－ＩＦＮ，一种长效ＩＦＮ）

[此贴子已经被作者于2003-4-19 7:03:07编辑过]