- 现金
- 2481 元
- 精华
- 5
- 帖子
- 855
- 注册时间
- 2002-3-30
- 最后登录
- 2012-7-8
|
1楼
发表于 2003-3-26 18:36
Treatment for Patients with Chronic Hepatitis B Failing Epivir-HBV (lamivudine) Therapy
Abstract Summary
Lamivudine (LAM)-resistant HBV develops in 16-32% of patients after one year and up to 69% after 5 years of LAM therapy.
Conducted in France, the aim of the current study was to evaluate the safety and efficacy of adefovir dipivoxil (ADV; Hepsera) 10mg in CHB patients with LAM-resistant HBV enrolled in the French early access program for adefovir10mg.
473 patients with chronic hepatitis B (CHB) failing >24 weeks LAM therapy, HBV DNA >105 copies/mL by PCR or positive by molecular hybridization, ALT >1.2 X ULN and METAVIR fibrosis score >F2 or activity score >A3 (>A2 for HIV/HBV co-infected patients) were enrolled.
Median treatment duration was 5.25 months (0.3 to 60 months) ; 88% male; 24% HIV/HBV co-infected; median age 49 years; 11% > 65 years. Five (1%) discontinued ADV: one for disease progression and four deaths unrelated to ADV.
Seventeen (3.6%) patients reported adverse drug reactions (ADRs) ; the most common were gastrointestinal (1.3%). No serious ADRs were reported.
Conclusion: Treatment with ADV 10 mg daily was well tolerated and resulted in significant reduction in serum HBV DNA, and ALT normalization in CHB patients with LAM-resistant HBV regardless of age or baseline fibrosis score.
[upload=gif]uploadImages/20033264332886137.gif[/upload]
03/21/03
Reference
F Zoulim?and others. ADEFOVIR DIPIVOXIL (ADV) FOR THE TREATMENT OF PATIENTS WITH CHRONIC HEPATITIS B (CHB) FAILING LAMIVUDINE (LAM) THERAPY. Abstract 3626.00. Abstracts of the 38th Annual Meeting of the European Association of the Study of the Liver (EASL).
|
|