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发表于 2002-11-7 17:24
Vaccine, Vol. 20 (29-30) (2002) pp. 3472-3476
Crown copyright © 2002 Published by Elsevier Science Ltd. All rights reserved.
PII: S0264-410X(02)00346-8
A novel hepatitis B vaccination regimen for adolescents: two doses 12 months apart
Leon G. Heron a * [email protected] , Kerry G. Chant a and Bin B. Jalaludin b
a South Western Sydney Public Health Unit, Liverpool Hospital, Locked Bag 7017, Sydney, NSW 1871, Australia
b South Western Sydney Epidemiology Unit, Liverpool Hospital, Sydney, NSW, Australia
Received 1 February 2002; received in revised form 22 April 2002; accepted 5 July 2002
Abstract
Background: Two- and three-dose hepatitis B vaccinations for adolescents are usually administered using dosing schedules of 6 months duration. This does not suit all circumstances. A 12-month schedule would be useful in schools and settings where only annual vaccination is the most practical option.
Aim: To examine the efficacy of a 12-month dosing interval for two-dose hepatitis B vaccination of adolescents.
Subjects: Four hundred and fifty-eight healthy first-year high school (Year 7) students.
Vaccination regimen: Engerix-B (GlaxoSmithKline Biologicals) 20µg: two doses, 12 months apart.
Serum collection: #1, same day as first vaccine dose given; #2, >1 month after second vaccine dose.
Results: Of the 458 children: 15 did not provide serum #1, 17 had prior vaccination, 2 had prior infection, 18 moved, 7 failed to provide serum #2, 12 withdrew (only 1 cited vaccine adverse reactions as the reason). Three hundred and eighty-seven (210 males, 177 females) aged 11.8-14.2 years (mean: 12.9±0.42 years) at entry completed both injections 321-381 days (mean: 359±10.7 days) apart and supplied serum #2, 30-57 days (mean: 41±5.6 days) after the second vaccine dose.
Anti-HBs responses: 379 of the 387 subjects (97.9%; 95% CI: 95.9-99.1%) achieved anti-HBs 10mIU/ml (range 10-170,460mIU/ml, geometric mean concentration (GMC) 4155mIU/ml95% CI of mean: 3381-5106mIU/ml). Sex was the only determinant of anti-HBs concentration (206 males: GMC 3073mIU/ml95% CI: 2285-4134mIU/ml; 173 females: GMC 5944mIU/ml95% CI: 4508-7851mIU/ml; P=0.001).
Conclusion: A high seroprotection rate and GMC were achieved using two 20µg doses of Engerix-B administered 12 months apart. These results are similar to those achieved by others using 6-month three- and two-dose regimens in adolescents.
Keywords: Hepatitis B vaccine; Two-dose vaccination; Twelve-month schedule; Adolescents
*Corresponding author. Tel.: +61-2-9828-5944; fax: +61-2-9828-5955.
Full text supplied by [ScienceDirect]
© Copyright 2002, Elsevier Science, All rights reserved.
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