人群减少后针对乙型肝炎病毒的抗体反应的持久性：一项来

StephenW

人群减少后针对乙型肝炎病毒的抗体反应的持久性：一项来自 10 年随访临床研究的回顾性多中心队列研究


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作者 He P, Xia J, Zhang P, Yang W, Xia Z, Liu P, Zhu Y, Fang Y, Zhang Z, Shen J

2022 年 10 月 12 日收到

接受出版 2022 年 12 月 2 日

2022 年 12 月 14 日出版 2022 卷：15 页 7389—7399

DOI https://doi.org/10.2147/IDR.S392262

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批准出版的编辑：Suresh Antony 教授
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何佩、1,2 夏杰、3 张佩新、3 杨文肃、1,2 夏兆新、1,2 刘平、4 朱一、1,2 方亚平、5 张振华、3 沈继禄1,2

1安徽医科大学第一附属医院检验医学科，合肥，中华人民共和国； 2安徽省公共卫生临床中心检验科，合肥，中华人民共和国； 3安徽医科大学第二医院感染科，合肥，中华人民共和国； 4界首市人民医院感染科，阜阳，中华人民共和国； 5安徽医科大学第二医院检验科，合肥，中华人民共和国

通讯员：张振华； 沉继路, Email [email protected]; [email protected]

目的：乙型肝炎表面抗体（HBsAb）在预防乙型肝炎病毒（HBV）感染中起重要作用，尤其是在免疫功能低下的个体和感染 HBV 的个体中。HBsAb 水平经常波动和降低。本研究旨在确定其规律性 HBsAb 在不同人群中的持久性。 此外，确定了风险因素和最佳临界值以预测 HBsAb 水平下降的人群。
方法：该研究涉及 182 名参与者，包括 76 名 HBsAb 水平下降 25% 的患者和 106 名 HBsAb 下降率 > 50% 的患者。 乙型肝炎核心抗体阴性和阳性患者均被纳入。对这些患者进行了 10 年的随访。 记录后续人口统计和实验室数据，并在各组之间进行比较。 评估了 HBsAb 数据和 HBsAb 持续免疫力的波动。 记录独立因素和最佳截止值。
结果：第4组的首次HBsAb中位数低于其他各组，中位数为50.8 mIU/mL。 此外，病例组的持续免疫时间短于对照组（p < 0.05）。 此外，既往 HBV 病史、使用抗病毒药物和低水平的首次 HBsAb 是抗体水平明显下降人群的独立危险因素。 另外，当HBsAb差异值的受试者工作特征曲线上的最佳截止值为8.53 mIU/mL时，对照组和病例组的敏感性和特异性分别为94%和70%。
结论：为保持对HBV感染的最佳免疫力，有HBV病史、服用抗病毒药物和/或HBsAb水平低的患者应及时重新接种乙肝疫苗。

关键词：人口减少，HBsAb 反应的持久性，独立危险因素，最佳临界值

StephenW

Durability of Antibody Response Against Hepatitis B Virus for a Decreased Crowd: A Retrospective Polycentric Cohort Study from a 10-Year Follow-Up Clinical Study
      

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Authors He P , Xia J, Zhang P, Yang W, Xia Z, Liu P, Zhu Y , Fang Y, Zhang Z , Shen J 

Received 12 October 2022

Accepted for publication 2 December 2022

Published 14 December 2022 Volume 2022:15 Pages 7389—7399

DOI https://doi.org/10.2147/IDR.S392262

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Suresh Antony
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Pei He,1,2 Jie Xia,3 Peixin Zhang,3 Wensu Yang,1,2 Zhaoxin Xia,1,2 Ping Liu,4 Yi Zhu,1,2 Yaping Fang,5 Zhenhua Zhang,3 Jilu Shen1,2

1Department of Laboratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Laboratory Medicine, Anhui Public Health Clinical Center, Hefei, People’s Republic of China; 3Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China; 4Department of Infectious Diseases, People’s Hospital of Jieshou City, Fuyang, People’s Republic of China; 5Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China

Correspondence: Zhenhua Zhang; Jilu Shen, Email [email protected]; [email protected]

Aim: Hepatitis B surface antibody (HBsAb) plays an important role in the prevention of hepatitis B virus (HBV) infection, especially in immunocompromised individuals and in those infected with HBV.HBsAb levels often fluctuate and decrease.This study aimed to determine the regularity of HBsAb persistence among different populations. Moreover, the risk factors and the optimal cutoff value were determined to predict a decreasing population in HBsAb level.
Methods: The study involved 182 participants, including 76 patients with a 25% decrease in HBsAb levels and 106 patients with an HBsAb decrease rate of > 50%. Both hepatitis B core antibody negative and positive patients were included.These patients were followed up for 10 years. The follow-up demographic and laboratory data were recorded and compared among the groups. Fluctuations in HBsAb data and HBsAb persistent immunity were evaluated. The independent factors and the optimal cutoff value were recorded.
Results: The first HBsAb median of Group 4 was lower than that of the other groups, and its median was 50.8 mlU/mL. In addition, the persistent immunity of the case groups was shorter than that of the control groups (p < 0.05). Furthermore, previous HBV history, use of antiviral drugs, and low levels of first HBsAb were independent risk factors in people with obviously decreased antibody levels. Also, when the optimum cutoff value on the receiver operating characteristic curve of the HBsAb difference value was taken as 8.53 mIU/mL, its sensitivity and specificity were 94% and 70% between the control and case groups, respectively.
Conclusion: To maintain optimal immunity against HBV infection, patients with a previous HBV history, those taking antiviral drugs, and/or those with low levels of HBsAb should be reimmunized with the hepatitis B vaccine in a timely manner.

Keywords: a decreasing population, durability of HBsAb response, independent risk factors, optimal cutoff value

StephenW

https://www.dovepress.com/getfile.php?fileID=86133

乙肝人1949

 发表于 2022-12-15 15:24 |只看该作者
我坚绝反对paxlovid和rna疫苗。1，paxlovid贵，而且不是100％有效率。2，rna在美国推广，但是也是反翻感染，新冠，且，说明，也不是100％预访新冠。昂贵。中美正在你死我活，的斗争。对美国的东西，能不用就不用。美国杀华为。我就是不用米国的。3，目前中米对抗，好多同事都说美国的各种药，急眼了，想打压科兴，邪恶的，让买米国货。。