肝细胞增殖有利于慢性乙型肝炎病毒感染幼儿的病毒清除

StephenW

肝细胞增殖有利于慢性乙型肝炎病毒感染幼儿的病毒清除
王立民#1、刘书红#2、王春亚#3、朱敏4、郭玉鹏5、赵潘2
隶属关系
隶属关系

    1
    北京清华长庚医院，清华大学，北京，中国。
    2
    中国人民解放军总医院第五医学中心（原北京302医院）
    3
    【作者单位】： 首都医科大学北京安贞医院;
    4
    中国人民解放军总医院第六医学中心，北京，中国。
    5
    牡丹江医科大学公共卫生学院，黑龙江省牡丹江市

#
同等贡献。

    PMID: 36239417 DOI: 10.1111/apa.16572

抽象的

目的：探讨慢性HBV感染幼儿肝细胞增殖与乙型肝炎病毒（HBV）清除的相关性。

方法：我们收集了与慢性 HBV 感染的儿科患者相对应的肝活检样本和临床数据。通过免疫组织化学染色评估肝组织中 Ki-67 的表达。

结果：纳入 18 名患者，根据不同的抗病毒结果分为 2 组。 I 组在 48 周内实现了乙型肝炎表面抗原 (HBsAg) 的丢失。第 II 组在 48 周后没有发生从乙型肝炎 e (HBe) 抗原到抗 HBe 的血清转化。 I组10例，II组8例。第一组和第二组血清中的人口统计学数据和基线病毒学和生化特征没有统计学差异。组织学上，第一组的平均 Ki-67 表达指数为 15%，而第二组的平均指数为 5%。两组有显着差异（P<0.01）。

结论：Ki-67 的高表达有助于慢性 HBV 感染幼儿的病毒清除。这是首次证实肝细胞增殖与体内 HBV 清除之间的关联，并对针对乙型肝炎的新治疗策略产生影响。

关键词：Ki-67；孩子们;乙型肝炎病毒;病毒清除。

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StephenW

Hepatocyte proliferation favors viral clearance in young children with chronic hepatitis B virus infection
Limin Wang #  1 , Shuhong Liu #  2 , Chunya Wang #  3 , Min Zhu  4 , Yupeng Guo  5 , Pan Zhao  2
Affiliations
Affiliations

    1
    Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
    2
    The Fifth Medical Center (formerly Beijing 302 Hospital), Chinese PLA General Hospital, Beijing, China.
    3
    Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
    4
    The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.
    5
    College of Public Health, Mudanjiang Medical University, Mudanjiang, Heilongjiang, China.

#
Contributed equally.

    PMID: 36239417 DOI: 10.1111/apa.16572

Abstract

Aim: To explore the correlation between hepatocyte proliferation and hepatitis B virus (HBV) clearance in young children with chronic HBV infection.

Methods: We collected liver biopsy samples and clinical data corresponding to paediatric patients with chronic HBV infection. Ki-67 expression in liver tissues was evaluated by immunohistochemical staining.

Results: Eighteen patients were included and were divided into 2 groups based on different antiviral outcomes. Group I achieved hepatitis B surface antigen (HBsAg) loss within 48 weeks. Group II did not develop seroconversion from hepatitis B e (HBe) antigen to anti-HBe after 48 weeks. There were 10 patients in Group I and 8 in Group II, respectively. Demographical data and baseline virological and biochemical characteristics in serum across Group I and Group II were not statistically different. Histologically, mean Ki-67 expression index in Group I was 15%, while the mean index in Group II was 5%. There was a significant difference between the two groups (P<0.01).

Conclusion: High Ki-67 expression can contribute to viral clearance in young children with chronic HBV infection. This is the first confirmation of the association between hepatocyte proliferation and HBV clearance in vivo and has implications for novel therapeutic strategies against hepatitis B.

Keywords: Ki-67; children; hepatitis B virus; viral clearance.

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