食物营养素的抗乙型肝炎病毒活性及潜在作用机制

StephenW

食物营养素的抗乙型肝炎病毒活性及潜在作用机制
亚历克西斯·何塞-阿布雷戈 1 、英格丽德·里维拉-伊尼格斯 1 、路易斯·托雷斯-雷耶斯 1 、索尼娅·罗曼 2
隶属关系
隶属关系

    1
    瓜达拉哈拉民用医院肝病基因组医学科，“Fray Antonio Alcalde”，瓜达拉哈拉，哈利斯科州，墨西哥。墨西哥哈利斯科州瓜达拉哈拉瓜达拉哈拉大学健康科学中心。
    2
    瓜达拉哈拉民用医院肝病基因组医学科，“Fray Antonio Alcalde”，瓜达拉哈拉，哈利斯科州，墨西哥。墨西哥哈利斯科州瓜达拉哈拉瓜达拉哈拉大学健康科学中心。电子地址：[email protected]。

    PMID: 36179798 DOI: 10.1016/j.aohep.2022.100766

免费文章
抽象的

乙型肝炎病毒 (HBV) 在世界许多地方流行，是导致慢性肝损伤和肝细胞癌的重要原因。 HBV 治疗因疾病阶段而异。终末期肝病患者的最佳治疗选择是肝移植，而对于慢性患者，HBV 感染通常使用抗病毒药物（核苷（酸）类似物或干扰素）进行管理。然而，由于可及性问题和抗病毒药物的高成本，大多数 HBV 患者无法获得治疗。这些并发症导致研究人员重新考虑治疗方法，例如营养疗法。本综述总结了据报道对 HBV 具有抗病毒活性的营养素及其可能的作用机制。最近的研究表明，白藜芦醇、维生素 E、乳铁蛋白、硒、姜黄素、木犀草素-7-O-葡萄糖苷、辣木提取物、绿原酸和表没食子儿茶素-3-没食子酸酯可能对乙型肝炎患者有益。这些营养素中的一部分已在体外和动物模型中进行了分析。对于这些营养素，已经提出了不同的抗病毒和保肝机制，例如激活抗氧化和抗炎途径、调节代谢稳态、表观遗传控制、激活 p53 基因、抑制癌基因、抑制病毒进入和诱导自噬体。总之，科学证据表明，HBV 的复制、转录和病毒抗原的表达可以直接受到营养物质的影响。未来，这些营养素可能会被考虑为乙肝患者制定适当的营养管理。

关键词： HBV感染；乙型肝炎病毒;抗病毒物质;营养素；治疗。

版权所有 © 2022。Elsevier España, S.L.U. 出版
利益冲突声明

利益冲突 无

StephenW

Anti-hepatitis B virus activity of food nutrients and potential mechanisms of action
Alexis Jose-Abrego  1 , Ingrid Rivera-Iñiguez  1 , Luis A Torres-Reyes  1 , Sonia Roman  2
Affiliations
Affiliations

    1
    Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde," Guadalajara, Jalisco, Mexico.; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico.
    2
    Department of Genomic Medicine in Hepatology, Civil Hospital of Guadalajara, "Fray Antonio Alcalde," Guadalajara, Jalisco, Mexico.; Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco, Mexico. Electronic address: [email protected].

    PMID: 36179798 DOI: 10.1016/j.aohep.2022.100766

Free article
Abstract

Hepatitis B virus (HBV) is endemic in many parts of the world and is a significant cause of chronic liver damage and hepatocellular carcinoma. HBV therapeutics vary according to the disease stage. The best therapeutic option for patients with end-stage liver disease is liver transplantation, while for chronic patients, HBV infection is commonly managed using antivirals (nucleos(t)ides analogs or interferons). However, due to the accessibility issues and the high cost of antivirals, most HBV patients do not have access to treatment. These complications have led researchers to reconsider treatment approaches, such as nutritional therapy. This review summarizes the nutrients reported to have antiviral activity against HBV and their possible mechanism of action. Recent studies suggest resveratrol, vitamin E, lactoferrin, selenium, curcumin, luteolin-7-O-glucoside, moringa extracts, chlorogenic acid, and epigallocatechin-3-gallate may be beneficial for patients with hepatitis B. The anti-HBV effect of most of these nutrients has been analyzed in vitro and in animal models. Different antiviral and hepatoprotective mechanisms have been proposed for these nutrients, such as the activation of antioxidant and anti-inflammatory pathways, regulation of metabolic homeostasis, epigenetic control, activation of the p53 gene, inhibition of oncogenes, inhibition of virus entry, and induction of autophagosomes. In conclusion, scientific evidence indicates that the HBV replication, transcription, and expression of viral antigens can be affected directly by nutrients. In the future, these nutrients may be considered to develop appropriate nutritional management for patients with hepatitis B.

Keywords: HBV infection; Hepatitis B virus; antiviral; nutrients; therapy.

Copyright © 2022. Published by Elsevier España, S.L.U.
Conflict of interest statement

Conflicts of interest None

StephenW

https://doi.org/10.1016/j.aohep.2022.100766