改进的铝佐剂与乙型肝炎病毒表面抗原混合时可引发更强的

StephenW

改进的铝佐剂与乙型肝炎病毒表面抗原混合时可引发更强的免疫反应
王志标 1 , 李书香 1 , 蒲山 1 , 多前卫 1 , 邵杰豪 1 , 专章 1 , 景旭 1
隶属关系
联系

    1
    国家疫苗血清研究所，北京经济技术开发区科创六街，北京 101111

    PMID：36188281 PMCID：PMC9521023 DOI：10.1021/acsomega.2c04266

抽象的

佐剂可以调节疫苗引发的免疫反应。传统的铝佐剂可以诱导体液免疫，但缺乏有效诱导Th1细胞免疫的能力，不利于开发具有改善保护作用的疫苗。不同来源的铝佐剂可能具有不同的理化性质，因此可以触发完全不同的免疫反应。这表明免疫系统对佐剂的识别及其反应与佐剂本身的物理化学性质密切相关。为了验证这一假设，在本研究中，我们开发了一种制备铝佐剂的新方法。这种铝助剂具有假勃姆石结构，蛋白质吸附能力强，悬浮稳定性好。使用乙型肝炎病毒表面抗原（HBsAg）作为免疫模型抗原测试佐剂；结果表明，这种铝佐剂不仅有效地诱导了体液免疫，而且还有效地诱导了细胞免疫反应。这些结果为提高佐剂的疗效提供了参考。

© 2022 作者。美国化学学会出版。
利益冲突声明

作者声明没有竞争的经济利益。

StephenW

Improved Aluminum Adjuvants Eliciting Stronger Immune Response When Mixed with Hepatitis B Virus Surface Antigens
Zhibiao Wang  1 , Shuxiang Li  1 , Pu Shan  1 , Duoqian Wei  1 , Shaojie Hao  1 , Zhuan Zhang  1 , Jing Xu  1
Affiliations
Affiliation

    1
    National Vaccine and Serum Institute, Ke Chuang 6th Street, Beijing Economic-Technological Development Area, Beijing 101111, China.

    PMID: 36188281 PMCID: PMC9521023 DOI: 10.1021/acsomega.2c04266

Abstract

Adjuvants can regulate the immune response triggered by vaccines. Traditional aluminum adjuvants can induce humoral immunity, but they lack the ability to effectively induce Th1 cellular immunity, which is not conducive to the development of vaccines with improved protective effects. Aluminum adjuvants from different sources may have different physicochemical properties, and therefore, completely different immune responses can be triggered. This suggests that adjuvant recognition by the immune system and its responses are closely associated with the physicochemical properties of the adjuvant itself. To test this hypothesis, in this study, we developed a new method for preparing an aluminum adjuvant. This aluminum adjuvant has a pseudoboehmite structure, strong protein adsorption capacity, and excellent suspension stability. The adjuvant was tested using the hepatitis B virus surface antigen (HBsAg) as a model antigen for immunization; the results showed that this aluminum adjuvant effectively induced not only humoral immunity but also an outstanding cellular immune response. These results provide a reference for improving the efficacy of adjuvants.

© 2022 The Authors. Published by American Chemical Society.
Conflict of interest statement

The authors declare no competing financial interest.

StephenW

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521023