针对慢性乙型肝炎的免疫疗法

StephenW

针对慢性乙型肝炎的免疫疗法

爱媛大学
在过去的 4 年中，两种主要类型的免疫疗法已被用于治疗慢性乙型肝炎。然而，HBV 抗原特异性免疫治疗似乎是安全有效的。学分：爱媛大学

乙型肝炎病毒 (HBV) 感染本质上是全球性的，可诱发多种肝脏疾病，如慢性乙型肝炎 (CHB)、肝硬化 (LC) 和肝细胞癌 (HCC)。 2019 年共有 882,000 名患者死于 HBV 相关肝病。如果为 CHB 患者提供适当的管理策略，可以控制如此大量的死亡和 HBV 发病率。

目前，有两种抗病毒药物获批用于治疗慢性乙型肝炎患者。然而，用这些抗病毒药物治疗的结果既不合理，也不对患者友好。这些药物具有主要的局限性，例如成本、无限使用、不良反应和低疗效。

根据检索到的信息，似乎免疫疗法可能是治疗慢性乙型肝炎患者的另一种治疗方法。在这篇文章中，它展示了为什么抗病毒药物和创新的抗病毒化合物在慢性乙型肝炎患者的治疗中作用有限。另一方面，通过提供科学证据和分析慢性乙型肝炎的作用机制，已经合理化了免疫疗法的范围。因此，已经提出了各种免疫疗法设计来治疗慢性乙型肝炎患者。

该研究发表在《胃肠病学杂志》上。

StephenW

Immune therapies against chronic hepatitis B

by Ehime University
Two main types of immune therapies have been employed to treat chronic hepatitis B during the last 4 decades. However, it seems that HBV-antigen-specific immune therapy may be safe and effective. Credit: Ehime University

Hepatitis B virus (HBV) infection is global in nature and induces several liver diseases, such as chronic hepatitis B (CHB), cirrhosis of the liver (LC) and hepatocellular carcinoma (HCC). A total of 882,000 patients died of HBV-related liver diseases in 2019. This large number of deaths and HBV morbidity can be contained if patients with CHB are provided with proper management strategies.

Currently, two varieties of antiviral drugs are approved for the treatment of CHB patients. However, the outcome of treatment with these antiviral drugs is neither rationally satisfactory nor patient-friendly. These drugs come with major limitations, such as cost, infinite usage, adverse effects, and low efficacy.

On the basis of the retrieved information, it seems that immune therapy may be an alternate therapeutic approach for treating CHB patients. In this article, it is shown why antiviral drugs and innovative antiviral compounds have limited roles in the treatment of CHB patients. On the other hand, the scope of immune therapies has been rationalized by providing scientific evidence and analyzing the mechanism of action of CHB. Therefore, various immune therapy designs have been proposed for treating CHB patients.

The research was published in the Journal of Gastroenterology .

StephenW

https://link.springer.com/article/10.1007/s00535-022-01890-8
https://link.springer.com/conten ... 535-022-01890-8.pdf