乙型肝炎相关肝细胞癌患者的长期生存和危险因素：真实世

StephenW

乙型肝炎相关肝细胞癌患者的长期生存和危险因素：真实世界研究
玉珠 1 2 , 顾玲玲 1 , 张发标 1 , 郑国群 1 , 陈婷 1 , 贾伟东 2
隶属关系
隶属关系

    1
    温州医科大学附属浙江省台州医院肝胰胆外科，台州 317000
    2
    中国科学技术大学第一附属医院肝外科, 生命科学与医学科, 合肥 230001

    PMID：36051249 PMCID：PMC9427325 DOI：10.1155/2022/7750140

抽象的

对2012年1月1日至2018年8月31日在中国科学技术大学第一附属医院接受根治性肝切除术的465例乙型肝炎相关肝细胞癌患者进行回顾性队列研究。收集临床、病理及随访资料，比较根治性切除术后死亡和非死亡的基本特征。 Kaplan-Meier 曲线用于生存分析和男性和女性亚组分析。多变量 Cox 比例风险回归模型用于分析与术后死亡相关的独立危险因素。 465例乙肝相关肝细胞癌根治性切除患者中，死亡132例，术后1年、3年、5年累计生存率分别为92.1%、78%、64%。在男性和女性亚组中，分别有 115 和 17 名患者死亡。男性的 1 年、3 年和 5 年累积生存率分别为 92.6%、77.0% 和 62.6%，女性分别为 89.6%、78.8% 和 70.2%。多因素Cox比例风险回归分析显示，微血管浸润（MVI）、Edmondson III/IV期、BCLC B期、总胆红素（TB）>20.5 μmol/L是乙肝相关肝细胞癌根治术后的独立危险因素。肝切除术。

版权所有 © 2022 于朱等。

StephenW

Long-Term Survival and Risk Factors in Patients with Hepatitis B-Related Hepatocellular Carcinoma: A Real-World Study
Yu Zhu  1   2 , Ling-Ling Gu  1 , Fa-Biao Zhang  1 , Guo-Qun Zheng  1 , Ting Chen  1 , Wei-Dong Jia  2
Affiliations
Affiliations

    1
    Department of Hepatopancreatobiliary Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou 317000, China.
    2
    Division of Liver Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.

    PMID: 36051249 PMCID: PMC9427325 DOI: 10.1155/2022/7750140

Abstract

A retrospective cohort study was conducted to collect 465 patients with hepatitis B-related hepatocellular carcinoma who had undergone radical hepatectomy from January 1, 2012, to August 31, 2018, at the First Affiliated Hospital of the University of Science and Technology of China. The clinical, pathological, and follow-up information was collected to compare the basic characteristics of death and nondeath after radical resection. Kaplan-Meier curves were used for survival analysis and male and female subgroup analysis. The multivariate Cox proportional-hazards regression model was used to analyze independent risk factors related to postoperative death. Of the 465 patients with radical resection of hepatitis B-related hepatocellular carcinoma, 132 died, and 1-, 3-, and 5-year cumulative survival rates after operation were 92.1%, 78%, and 64%, respectively. In the male and female subgroup, 115 and 17 patients died, respectively. The 1-, 3-, and 5-year cumulative survival rates were 92.6%, 77.0%, and 62.6%, respectively, in men, and 89.6%, 78.8%, and 70.2%, respectively, in women. Multivariate Cox proportional-hazards regression analysis showed that microvascular invasion (MVI), Edmondson III/IV, BCLC stage B, and total bilirubin (TB) > 20.5 μmol/L were independent risk factors in patients with hepatitis B-related hepatocellular carcinoma after radical hepatectomy.

Copyright © 2022 Yu Zhu et al.

StephenW

https://downloads.hindawi.com/journals/cjgh/2022/7750140.pdf