血清维生素 D 对代谢相关性脂肪肝的影响：一项基于人群的

StephenW

血清维生素 D 对代谢相关性脂肪肝的影响：一项基于人群的大型研究
关雅琪
, 徐一伦
, 黄素
ORCID Icon，孙学诚
, 李艳轩
& 王婷婷
第 862-871 页 | 2021 年 12 月 4 日收到，2022 年 2 月 1 日接受，在线发表：2022 年 2 月 16 日

    下载引文 https://doi.org/10.1080/00365521.2022.2039284 CrossMark Logo CrossMark

抽象的
背景

多项研究表明，血清维生素D是代谢相关性脂肪肝（MAFLD）的重要因素，但一直没有一致的结论。
方法

在接受健康检查的 427,507 名受试者中，符合纳入标准的 83,625 名被纳入横断面分析。收集临床和实验室数据进行分析。通过腹部影像学诊断MAFLD。
结果

多变量线性回归模型发现血清维生素 D 与 MAFLD 之间存在负相关（OR：0.92，95% CI：0.90 至 0.94，p = .001），在调整了其他明确的风险因素后。当血清维生素 D 作为分类变量（四分位数，Q1-Q4）（Q4 与 Q1，OR：0.82，95% CI：0.77 至 0.87，p < .001）和显着线性观察到趋势（趋势 p <.001）。经分析，血清维生素D与MAFLD呈非线性关系，拐点为2.23（44.6 nmol/L或17.84 ng/mL）。拐点左右两侧的效应量和置信区间分别为 1.16（1.06 到 1.28）和 0.89（0.86 到 0.91）。与 MAFLD 的所有相互作用对年龄、性别、糖尿病、高血压、吸烟和体重指数均不显着（p 分别为相互作用 = .110、.558、.335、.195、.616 和 .401）。
结论

血清维生素D与MAFLD之间存在非线性关系。当血清维生素D水平≥44.6 nmol/L（17.84 ng/mL）时，检测到血清维生素D与MAFLD呈负相关。低于此水平，血清维生素 D 可能会促进 MAFLD 的进展。

关键词： 血清维生素 DMAFL 关联非线性相关 回顾性

StephenW

Effect of serum vitamin D on metabolic associated fatty liver disease: a large population-based study
Yaqi Guan
, Yilun Xu
, Huang Su
ORCID Icon, Xuecheng Sun
, Yanxuan Li
& Tingting Wang
Pages 862-871 | Received 04 Dec 2021, Accepted 01 Feb 2022, Published online: 16 Feb 2022

    Download citation https://doi.org/10.1080/00365521.2022.2039284 CrossMark Logo CrossMark

Abstract
Background

Several studies have revealed that serum vitamin D is an important factor for metabolic associated fatty liver disease (MAFLD), but there had been no consistent conclusion.
Methods

Of 427,507 subjects who underwent health examination, 83,625 who met the inclusion criteria were included in a cross-sectional analysis. Clinical and laboratory data were collected for analysis. MAFLD was diagnosed by abdominal imaging.
Results

Multivariate linear regression models discovered a negative association between serum vitamin D and MAFLD (OR: 0.92, 95% CI: 0.90 to 0.94, p = .001), after adjusting for other well-identified risk factors. The same result was found when serum vitamin D was handled as a categorical variable (quartile, Q1–Q4) (Q4 vs. Q1, OR: 0.82, 95% CI: 0.77 to 0.87, p < .001), and a significant linear trend was observed (p for trend <.001). After analysis, a nonlinear relationship was detected between serum vitamin D and MAFLD, with an inflection point of 2.23 (44.6 nmol/L or 17.84 ng/mL). The effect sizes and the confidence intervals on the left and right sides of the inflection point were 1.16 (1.06 to 1.28) and 0.89 (0.86 to 0.91), respectively. All interactions with MAFLD were not significant for age, sex, diabetes, hypertension, smoking and body mass index (p for interaction = .110, .558, .335, .195, .616 and .401, respectively).
Conclusions

There was a nonlinear relationship between serum vitamin D and MAFLD. When the serum vitamin D level was ≥44.6 nmol/L (17.84 ng/mL), a negative correlation between serum vitamin D and MAFLD was detected. Below this level, serum vitamin D might promote the progression of MAFLD.

Keywords: Serum vitamin DMAFLDassociationnonlinear correlationretrospective