慢性乙型肝炎的新治疗策略

StephenW

慢性乙型肝炎的新治疗策略
桑德拉菲利普斯 1 , 拉维贾加蒂亚 1 , 希尔帕乔克希 1
隶属关系
联系

    1
    英国伦敦肝脏研究基金会、免疫学和微生物科学学院、英国伦敦国王学院。

    PMID：35763282 DOI：10.1080/21505594.2022.2093444

抽象的

过去几年，乙型肝炎药物管线的活动复苏，许多化合物处于不同的开发阶段。本综述旨在全面概述慢性乙型肝炎 (CHB) 治疗的最新进展。我们将讨论临床开发中广泛的直接作用抗病毒药物，包括衣壳抑制剂、siRNA、HBsAg 和聚合酶抑制剂。此外，还将广泛回顾宿主靶向疗法（HTT），重点关注免疫治疗的最新进展，如toll样受体和RIG-1激动剂、治疗性疫苗和免疫检查点调节剂。越来越多处于临床前开发阶段的 HTT 直接针对 HBV 持久性的关键，即共价闭合环状 DNA (cccDNA)，并为 HBV 治愈带来了巨大希望。将重点介绍这一激动人心的 HBV 研究领域，并讨论诸如亲环蛋白抑制剂、APOBEC3 脱氨酶和表观遗传修饰剂等分子。

关键词：慢性乙型肝炎；直接作用的抗病毒药物；治疗目标； cccDNA；宿主靶向治疗。
出版物类型

    审查

StephenW

Novel therapeutic strategies for Chronic Hepatitis B
Sandra Phillips  1 , Ravi Jagatia  1 , Shilpa Chokshi  1
Affiliations
Affiliation

    1
    Institute of Hepatology Foundation for Liver Research London UK, School of Immunology and Microbial Sciences King's College London, UK.

    PMID: 35763282 DOI: 10.1080/21505594.2022.2093444

Abstract

The last few years have seen a resurgence of activity in the hepatitis B drug pipeline, with many compounds in various stages of development. This review aims to provide a comprehensive overview of the latest advances in therapeutics for chronic hepatitis B (CHB). We will discuss the broad spectrum of direct-acting antivirals in clinical development, including capsids inhibitors, siRNA, HBsAg and polymerase inhibitors. In addition, host-targeted therapies (HTT) will be extensively reviewed, focusing on the latest progress in immunotherapeutics such as toll-like receptors and RIG-1 agonists, therapeutic vaccines and immune checkpoints modulators. A growing number of HTT in pre-clinical development directly target the key to HBV persistence, namely the covalently closed circular DNA (cccDNA) and hold great promise for HBV cure. This exciting area of HBV research will be highlighted, and molecules such as cyclophilins inhibitors, APOBEC3 deaminases and epigenetic modifiers will be discussed.

Keywords: Chronic hepatitis B; Direct-acting antivirals; Therapeutic targets; cccDNA; host-targeted therapies.
Publication types

    Review

StephenW

https://www.tandfonline.com/doi/ ... 444?needAccess=true

lancas

免疫治疗又有关注点了，好事好事~