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肝胆相照论坛 论坛 学术讨论& HBV English ClearB Therapeutics 宣布接受摘要强调临床前慢性乙型肝 ...
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ClearB Therapeutics 宣布接受摘要强调临床前慢性乙型肝炎数据作 [复制链接]

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发表于 2022-6-16 15:38 |只看该作者 |倒序浏览 |打印
ClearB Therapeutics 宣布接受摘要强调临床前慢性乙型肝炎数据作为 EASL 2022 的海报展示
东部夏令时间 2022 年 6 月 15 日上午 9:16

马萨诸塞州康科德--(BUSINESS WIRE)--(美国商业资讯)--开发 CLB-3000(一种旨在推动乙型肝炎功能性治愈的治疗性疫苗)的公司 ClearB Therapeutics, Inc. 今天宣布,其摘要题为“使用 CLB-3000 进行治疗性疫苗接种”在慢性乙型肝炎的小鼠模型中诱导与功能性治愈相关的抗 HBs 反应”在英国伦敦举行的 2022 年欧洲肝脏研究协会 (EASL) 国际肝脏大会 (ILC) 上被接受为海报展示2022 年 6 月 22 日至 26 日。
   
“随着我们继续推进我们的候选治疗性疫苗 CLB-3000,朝着第一个人体试验方向发展,我们很高兴能与乙型肝炎社区分享我们的临床前数据,”该公司首席执行官 Aileen Rubio 博士说。 “慢性乙型肝炎感染 (CHB) 仍然是一种重要疾病,迄今为止,功能性治愈一直难以捉摸,可能需要联合治疗。我们相信,通过联合使用 ClearB 的治疗性疫苗,对患者的免疫系统进行再教育,以打破对慢性 HBV 感染的耐受性,这可能成为此类治疗方案的重要组成部分。”

摘要编号:723 / SAT362
摘要标题:在慢性乙型肝炎小鼠模型中使用 CLB-3000 治疗性疫苗接种诱导与功能性治愈相关的抗 HBs 反应
日期:2022 年 6 月 25 日星期六
时间:格林威治标准时间+1 上午 9:00
演讲者姓名:Aileen Rubio 博士,ClearB Therapeutics

有关 EASL 2022 的更多信息,请访问
https://easl.eu/event/international-liver-congress-2022/

关于 ClearB Therapeutics
ClearB Therapeutics 于 2017 年由 Morningside Ventures 与 Stephen Locarnini 教授和澳大利亚墨尔本的维多利亚传染病参考实验室共同创立。 ClearB 正致力于开发旨在推动乙型肝炎功能性治愈的治疗性疫苗。这项工作的基础是从研究慢性乙型肝炎患者的罕见感染解决方案中获得的专有见解。有关更多信息,请访问 https:// clearbtherapeutics.com/。

关于晨兴创投:晨兴由陈氏家族于 1986 年创立,在北美、欧洲和亚太地区进行私募股权和风险投资。在生命科学领域,晨兴专注于生物制药产品的早期(临床前通过人类概念验证)投资。他们与学术创始人和企业家合作,建立世界级的公司,希望显着改善当今医学的现状,最终改善患者的生活。晨兴的重点是投资于优秀的生物医学研究,其中已经收集了大量的知识,并且在临床开发方面有一条可行的道路。他们的使命是为对人类疾病的预防或治疗产生有意义的积极影响做出贡献,并相信只要实现这一目标,商业成功就会随之而来。


联系人

Jennifer Locke,首席运营和商务官
ClearB Therapeutics, Inc.
[email protected]

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发表于 2022-6-16 15:38 |只看该作者

ClearB Therapeutics Announces Acceptance of Abstract Highlighting Pre-Clinical Chronic Hepatitis B Data as a Poster Presentation at EASL 2022
June 15, 2022 09:16 AM Eastern Daylight Time

CONCORD, Mass.--(BUSINESS WIRE)--ClearB Therapeutics, Inc., a company developing CLB-3000, a therapeutic vaccine designed to drive functional cure of hepatitis B, announced today that its abstract entitled ‘Therapeutic vaccination with CLB-3000 in a mouse model of chronic Hepatitis B induces anti-HBs responses associated with functional cure’ was accepted for poster presentation at the European Association for the Study of the Liver (EASL) International Liver Congress (ILC) 2022, taking place in London, UK June 22 - 26, 2022.
   
“As we continue to progress our therapeutic vaccine candidate, CLB-3000, toward first in human trials, we are excited to share our preclinical data with the Hepatitis B community,” said Aileen Rubio, PhD., CEO for the company. “Chronic infection with Hepatitis B (CHB) remains a significant disease, where functional cure has so far been elusive and combination therapies are likely needed. We believe that re-education of patients’ immune systems to break tolerance of their chronic HBV infections through co-administration of ClearB’s therapeutic vaccine could become an important component of such treatment regimens.”

Abstract Number: 723 / SAT362
Abstract Title : Therapeutic vaccination with CLB-3000 in a mouse model of chronic Hepatitis B induces anti-HBs responses associated with functional cure
Date: Saturday, June 25, 2022
Time: 9:00 AM GMT+1
Presenter Name: Dr. Aileen Rubio, ClearB Therapeutics

For more information regarding EASL 2022 please visit
https://easl.eu/event/international-liver-congress-2022/

About ClearB Therapeutics
ClearB Therapeutics was co-founded in 2017 by Morningside Ventures in collaboration with Professor Stephen Locarnini and the Victoria Infectious Diseases Reference Laboratory in Melbourne, Australia. ClearB is working to develop therapeutic vaccines designed to drive functional cure of hepatitis B. The work is grounded in proprietary insights derived from studying rare-event infection resolution in patients who suffer from chronic hepatitis B. For more information, please visit https://clearbtherapeutics.com/.

About Morningside Ventures: Morningside was founded in 1986 by the Chan family, to make private equity and venture capital investments in North America, Europe, and Asia Pacific. In the life sciences, Morningside specializes in early-stage (pre-clinical through human proof-of-concept) investments in biopharmaceutical products. They partner with academic founders and entrepreneurs to build world-class companies that want to markedly improve the current state of medicine today and ultimately, the lives of patients. Morningside's focus is to invest in excellent biomedical research, where a significant body of knowledge has been gathered and there is a plausible path forward in clinical development. Their mission is to contribute to making a meaningful, positive impact on the prevention or treatment of human disease, and believe that so long as this is achieved, commercial success will follow.


Contacts

Jennifer Locke, Chief Operating & Business Officer
ClearB Therapeutics, Inc.
[email protected]
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