丹麦普通人群中慢性乙型肝炎病毒感染者与健康人的死亡率

StephenW

丹麦普通人群中慢性乙型肝炎病毒感染者与健康人的死亡率和死因
Signe Bollerup 1 , Sofie Hallager 1 , Frederik Engsig 1 , Amanda Mocroft 2 3 , Henrik Krarup 4 5 , Lone G Madsen 6 7 , Peter Thielsen 8 , Ulla Balslev 9 , Helene Mens 10 , Toke S Barfod 11 , Mette R Clausen 12 , Lise Hobolth 13、Alex L Laursen 14、Britta Tarp 15、Birgit T Roege 16、Jesper B Hansen 5、Lone Mygind 17、Peer B Christensen 18 19、Jan Gerstoft 7 20、Nina Weis 1 7
隶属关系

    PMID：35633092 DOI：10.1111/jvh.13713

抽象的

该研究旨在确定慢性乙型肝炎病毒 (HBV) 感染者与年龄和性别匹配的普通人群相比的调整后全因死亡率和死因。我们使用全国登记册来识别 2002-2017 年在丹麦年龄 ≥ 18 岁的慢性 HBV 感染者，每个人包括 10 名年龄和性别匹配的对照。随访时间为诊断后 6 个月，直至死亡、移民或 2017 年 12 月 31 日。根据年龄、性别、就业、出身和合并症调整的死亡率比 (MRR) 使用泊松回归计算。假设泊松分布，计算了具有 95% 置信区间的未经调整的特定原因死亡率比。共纳入 6,988 名慢性 HBV 感染者和 69,847 名对照者。在 7.7 年的中位随访期间（范围 0.0-15.5），315 名（5%）患有慢性 HBV 感染者和 1,525 名（2%）没有慢性 HBV 感染者死亡。调整后的全因 MRR 为 1.5 (95% CI 1.2-2.0)。慢性 HBV 感染者因肝病（MRR 12.3 [8.6-17.7]）、外因（MRR 3.3 [2.5-4.7]）、内分泌疾病（MRR 3.2 [1.8-5.4]）、泌尿生殖系统疾病导致死亡率增加。疾病（MRR 3.2 [1.2-7.6]）和肿瘤（肝细胞癌除外；MRR 1.6 [1.2-2.0]）。总之，这项研究表明，与年龄和性别匹配的没有慢性 HBV 感染的人相比，慢性 HBV 感染者的全因死亡率增加，在调整了几个混杂因素后仍然存在。超额死亡率主要与肝脏疾病有关，但也与外部因素、内分泌疾病、泌尿生殖系统疾病和肿瘤（不包括肝细胞癌）有关。

关键词：丹合；乙型肝炎；斯堪的纳维亚；总人口;全国。

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StephenW

Mortality and cause of death in persons with chronic hepatitis B virus infection versus healthy persons from the general population in Denmark
Signe Bollerup  1 , Sofie Hallager  1 , Frederik Engsig  1 , Amanda Mocroft  2   3 , Henrik Krarup  4   5 , Lone G Madsen  6   7 , Peter Thielsen  8 , Ulla Balslev  9 , Helene Mens  10 , Toke S Barfod  11 , Mette R Clausen  12 , Lise Hobolth  13 , Alex L Laursen  14 , Britta Tarp  15 , Birgit T Roege  16 , Jesper B Hansen  5 , Lone Mygind  17 , Peer B Christensen  18   19 , Jan Gerstoft  7   20 , Nina Weis  1   7
Affiliations

    PMID: 35633092 DOI: 10.1111/jvh.13713

Abstract

The study aimed to determine adjusted all-cause mortality and cause of death in persons with chronic hepatitis B virus (HBV) infection compared with age - and sex-matched persons from the general population. We used nationwide registers to identify persons aged ≥ 18 years with chronic HBV infection in 2002-2017 in Denmark and included 10 age- and sex matched controls for each. Follow up was from 6 months after diagnosis until death, emigration, or December 31, 2017. Mortality rate ratios (MRRs) adjusted for age, sex, employment, origin, and comorbidity were calculated using Poisson regression. Unadjusted cause specific mortality rate ratios with 95% confidence intervals were calculated assuming a Poisson distribution. A total of 6,988 persons with chronic HBV infection and 69,847 controls were included. During a median follow up of 7.7 years (range 0.0-15.5), 315 (5%) persons with - and 1,525 (2%) without - chronic HBV infection died. The adjusted all-cause MRR was 1.5 (95% CI 1.2-2.0). Persons with chronic HBV infection had increased mortality due to liver disease including hepatocellular carcinoma (MRR 12.3 [8.6-17.7]), external causes (MRR 3.3 [2.5-4.7]), endocrine disease (MRR 3.2 [1.8-5.4]), genitourinary disease (MRR 3.2 [1.2-7.6]) and neoplasms (except hepatocellular carcinoma; MRR 1.6 [1.2-2.0]). In conclusion, this study showed an increased all-cause mortality in persons with chronic HBV infection in comparison with age- and sex-matched persons without chronic HBV infection which remained after adjustment for several confounding factors. Excess mortality was mainly associated with liver disease, but also external factors, endocrine disease, genitourinary disease, and neoplasms (excluding hepatocellular carcinoma).

Keywords: DANHEP; Hepatitis B; Scandinavia; general population; nationwide.

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lancas

~~~~好像有病身体肯定会差一些~~~