更新越南人群血清丙氨酸转氨酶值的正常上限

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更新越南人群血清丙氨酸转氨酶值的正常上限

    Nguyen Thi Cam Huong1, Sedighe Karimzadeh2, Nguyen Thi Thanh3, Tieu Minh Thuan4, Ghada Mohamed Sabbah5, Khaled Ismaeil6, Dang Nguyen Trung An7, Lai To Huong8, http://orcid.org/0000-0002-9543-9440Nguyen Tien Huy9,范氏乐和10

    与 Nguyen Tien Huy 博士的通信； [email protected]；范氏乐和博士； [email protected]; Nguyen Thi Cam Huong 博士； [email protected]

抽象的

背景丙氨酸氨基转移酶（ALT）是肝损伤的标志物，其范围受病毒性肝炎、酒精性肝炎和非酒精性脂肪肝疾病的影响。我们旨在研究与较高 ALT 水平相关的因素，并更新越南人群的正常上限 (ULN)。

方法 这项横断面研究纳入了 8383 名年龄在 18 岁及以上的成年人，他们在胡志明市医疗中心进行了健康检查。按照排除标准，6677 名受试者被纳入分析。

结果 年龄≤40岁，男性，体重指数>23 kg/m2，舒张压>85 mm Hg，胆固醇>5.2 mmol/L，甘油三酯>1.7 mmol/L，阳性，抗丙型肝炎病毒阳性，脂肪肝脏 (p<0.05) 与较高的 ALT 水平 (>40 U/L) 相关。在不考虑年龄和性别的情况下，在排除具有上述影响因素之一的参与者后定义健康组。健康组的中位 ALT 水平男性为 18，女性为 13。健康组第 95 个百分位的 ULN 为男性 40 U/L，女性为 28 U/L。

结论 健康女性的 ALT ULN 低于健康男性。更新了 ALT 水平的 ULN 可以促进对不健康受试者的识别。需要更多涉及种族和生活方式因素的研究来确认越南人口中的新 ULN。

StephenW

Updated upper limit of normal for serum alanine aminotransferase value in Vietnamese population

    Nguyen Thi Cam Huong1, Sedighe Karimzadeh2, Nguyen Thi Thanh3, Tieu Minh Thuan4, Ghada Mohamed Sabbah5, Khaled Ismaeil6, Dang Nguyen Trung An7, Lai To Huong8, http://orcid.org/0000-0002-9543-9440Nguyen Tien Huy9, Pham Thi Le Hoa10

    Correspondence to Dr Nguyen Tien Huy; [email protected]; Dr Pham Thi Le Hoa; [email protected]; Dr Nguyen Thi Cam Huong; [email protected]

Abstract

Background Alanine aminotransferase (ALT) is a marker of hepatic damage and its range can be affected by viral hepatitis, alcoholic hepatitis and non-alcoholic fatty liver diseases. We aimed to study the factors associated with higher ALT level and update the upper limit of normal (ULN) in the Vietnamese population.

Methods This cross-sectional study enrolled 8383 adults, aged 18 years and older who visited the Medical Center at Ho Chi Minh City for a health check-up. Following the exclusion criteria, 6677 subjects were included in the analysis.

Results Age ≤40 years, male gender, body mass index >23 kg/m2, diastolic blood pressure >85 mm Hg, cholesterol >5.2 mmol/L, triglyceride >1.7 mmol/L, positivity, anti-hepatitis C virus positivity and fatty liver (p<0.05) were associated with higher ALT level (>40 U/L). Without considering age and gender, healthy group is defined after exclusion of participants with one of the mentioned contributing factors. The median ALT level in the healthy group was 18 in men and 13 in women. The ULN at the 95th percentile of the healthy group was 40 U/L in men and 28 U/L in women.

Conclusion The ULN for ALT in healthy women was lower than in healthy men. Updated ULN for ALT level can promote the identification of unhealthy subjects. More studies that involve ethnicity and lifestyle factors are needed to confirm the new ULN in the Vietnamese population.

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https://bmjopengastro.bmj.com/co ... /1/e000870.full.pdf