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Breakthroughs in hepatology
Norah A. Terrault
Jean-François Dufour
Robert F. Schwabe
Vincent Wai-Sun Wong
DOI:https://doi.org/10.1016/j.jhep.2022.04.001
In medicine, nothing is more satisfying than witnessing the accumulation of knowledge through research efforts and the transformation of clinical practice that follows. Many colleagues from our generation remember the days when we struggled to care for patients with chronic viral hepatitis, with few therapies to offer and the inevitable deterioration in some patients over time. Fast forward to the present where chronic hepatitis C infection is eradicated with 8 to 12 weeks of direct-acting antivirals and essentially 100% of patients treated with entecavir or tenofovir for chronic hepatitis B achieve sustained viral suppression. Moreover, these highly effective treatments have translated into meaningful reductions in liver-related morbidity and mortality. Liver transplantation, once viewed as radical and risky, is now a standard of care in patients with end-stage liver disease and is associated with excellent long-term survival. We are indeed the beneficiaries of decades of innovation and breakthroughs |
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