接受抗病毒治疗超过 9 年的慢性乙型肝炎患者中乙型肝炎病

StephenW

接受抗病毒治疗超过 9 年的慢性乙型肝炎患者中乙型肝炎病毒前基因组 RNA 的动态
潘佳丽 1 , 于田 2 , 徐景航 1 , 郝洛 3 , 宁潭 1 , 韩一凡 1 , 钱康 1 , 陈宏宇 1 , 杨玉清 1 , 徐晓媛 1
隶属关系
隶属关系

    1
    北京大学第一医院感染科;
    2
    北京大学第一医院消化内科;
    3
    中国医学科学院老年医学研究所北京医院国家老年医学中心消化内科

    PMID：35572978 PMCID：PMC9099358 DOI：10.3389/fmed.2022.851717

抽象的

血清乙型肝炎病毒前基因组 RNA (HBV pgRNA) 是一种与共价闭合环状 DNA 相关的潜在生物标志物。需要探索慢性乙型肝炎患者中 HBV pgRNA 的长期动态。招募了 100 名接受过核苷（酸）类似物治疗的慢性乙型肝炎患者，以分析 9 年来 HBV pgRNA 的动态。 HBV pgRNAs的阳性率逐渐下降，呈双相动力学。接受恩替卡韦治疗的患者血清 HBV pgRNA 水平转为阴性的时间晚于接受阿德福韦或拉米夫定治疗的患者。治疗 9 年后仍为 HBV pgRNA 阳性的患者可能具有更高的病毒转录效率。基线时乙型肝炎e抗原（HBeAg）阳性患者的逆转录效率高于HBeAg阴性患者，并且在核苷（酸）类似物治疗24周后无差异。不同特征的患者血清HBV pgRNA阴性转化的轨迹不同。长期动态监测血清HBV pgRNA水平对乙肝治疗具有重要意义。

关键词：PgRNA；慢性乙型肝炎；动力学;乙型肝炎病毒;转录。

版权所有 © 2022 Pan, Tian, Xu, Luo, Tan, Han, Kang, Chen, Yang and Xu。

StephenW

Dynamics of Hepatitis B Virus Pregenomic RNA in Chronic Hepatitis B Patients With Antiviral Therapy Over 9 Years
Jiali Pan  1 , Yu Tian  2 , Jinghang Xu  1 , Hao Luo  3 , Ning Tan  1 , Yifan Han  1 , Qian Kang  1 , Hongyu Chen  1 , Yuqing Yang  1 , Xiaoyuan Xu  1
Affiliations
Affiliations

    1
    Department of Infectious Diseases, Peking University First Hospital, Beijing, China.
    2
    Department of Gastroenterology, Peking University First Hospital, Beijing, China.
    3
    Department of Gastroenterology, National Center of Gerontology, Beijing Hospital, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.

    PMID: 35572978 PMCID: PMC9099358 DOI: 10.3389/fmed.2022.851717

Abstract

Serum hepatitis B virus pregenomic RNA (HBV pgRNA) is a potential biomarker that is correlated with covalently closed circular DNA. The long-term dynamics of HBV pgRNA in patients with chronic hepatitis B need to be explored. One hundred naïve nucleos(t)ide analog-treated patients with chronic hepatitis B were enrolled to analyze the dynamics of HBV pgRNA over 9 years. The positive rates of HBV pgRNAs declined gradually and showed biphasic kinetics. Serum HBV pgRNA levels in patients treated with entecavir became negative later than those treated with adefovir or lamivudine. Patients who remain positive for HBV pgRNA after 9 years of treatment may have higher viral transcription efficiencies. The reverse transcription efficiency of hepatitis B e-antigen (HBeAg)-positive patients was higher than that of HBeAg-negative patients at baseline and showed no difference after 24-week nucleos(t)ide analog treatment. The trajectory of serum HBV pgRNA-negative transformation differs in patients with different characteristics. Long-term dynamic monitoring of serum HBV pgRNA levels has significance in hepatitis B treatment.

Keywords: PgRNA; chronic hepatitis B; dynamics; hepatitis B virus; transcription.

Copyright © 2022 Pan, Tian, Xu, Luo, Tan, Han, Kang, Chen, Yang and Xu.

StephenW

https://www.frontiersin.org/articles/10.3389/fmed.2022.851717/pdf