确定全球乙型肝炎病毒 C 基因型在人类中的起源和传播

StephenW

确定全球乙型肝炎病毒 C 基因型在人类中的起源和传播
李天泽 1 , 陈慧 2 , 孙立勤 3 , 刘家业 4 5
隶属关系
隶属关系

    1
    郑州大学公共卫生学院流行病学与卫生统计系，河南郑州。
    2
    中国人民解放军疾病预防控制中心，北京，中国。
    3
    【作者单位】： 南方科技大学深圳市第三人民医院传染病国家临床研究中心;
    4
    深圳大学医学部公共卫生学院，中国深圳。
    5
    山东省疾病预防控制中心扩大计划免疫处，济南，中国。

    PMID：35491234 DOI：10.5582/ddt.2022.01030

抽象的

乙型肝炎病毒基因 C 型 (HBV/C) 是全球最流行的 HBV 毒株之一，尤其是在西太平洋和东南亚地区。然而，HBV/C 的起源和进化时间尺度在很大程度上仍未得到解决。我们使用贝叶斯马尔可夫链蒙特卡罗（MCMC）方法分析了全球采样的 101 个全基因组 HBV/C 序列的进化速率和分子时钟系统发育。我们通过贝叶斯随机搜索变量选择 (BSSVS) 推断了全球 HBV/C 的时空动态。我们发现 HBV/C 基因型全基因组的估计平均进化率为 4.32 × 10-5 亚/位点/年（95% 最高后验密度 3.02 × 10-6 - 8.97 × 10-5）。系统地理学重建能够在公元 715 年左右确定澳大利亚全球 HBV/C 起源的单一位置。C4 亚基因型分化最早，主要在澳大利亚传播，C1 主要在东南亚，C2 主要在东亚，C3 在偏远地区大洋洲。 HBV感染的有效数量在1760年代和1860年代之间呈指数级快速增长，此后一直保持高水平直到现在。我们的研究首次提供了 HBV/C 流行的估计时间尺度，并为 HBV/C 在全球人类中的传播提供了新的见解。基于高效病毒种群的持续存在，本研究提供了从基于人群的分子水平到 2030 年消除 HBV 的挑战的进一步证据，并呼吁政策制定者、卫生提供者和社会共同努力全球化的世界。

关键词：HBV基因型C；乙型肝炎病毒;进化;系统发育;系统地理学

StephenW

Dating the origin and dispersal of global hepatitis B virus genotype C in humans
Tianze Li  1 , Hui Chen  2 , Liqin Sun  3 , Jiaye Liu  4   5
Affiliations
Affiliations

    1
    Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
    2
    Center for Disease Control and Prevention of Chinese People's Liberation Army, Beijing, China.
    3
    National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.
    4
    School of Public Health, Shenzhen University Health Science Center, Shenzhen, China.
    5
    Expanded Program Immunization Division, Shandong Provincial Center for Disease Control and Prevention, Jinan, China.

    PMID: 35491234 DOI: 10.5582/ddt.2022.01030

Abstract

Hepatitis B virus genotype C (HBV/C) is one of the most prevalent HBV strains worldwide, especially in the Western Pacific and the South-East Asia. However, the origin and evolutionary timescale of HBV/C remains largely unresolved. We analyzed the evolutionary rate and molecular clock phylogeny of 101 full-genome HBV/C sequences sampled globally using a Bayesian Markov Chain Monte Carlo (MCMC) approach. We inferred the spatiotemporal dynamics of the HBV/C worldwide by the Bayesian Stochastic Search Variable Selection (BSSVS). We found that the estimated mean evolution rate of the HBV/C genotype full-genome was 4.32 × 10-5 subs/site/year (95% highest posterior density 3.02 × 10-6 - 8.97 × 10-5). Phylogeographic reconstruction was able to identify a single location for the origin of the global HBV/C in Australia around A.D. 715. The subgenotype C4 diverged earliest and mainly circulated in Australia, C1 mainly in Southeast Asia, C2 mainly in East Asia and C3 in Remote Oceania. The effective number of HBV infection presented a rapid exponential increase between the 1760s and 1860s followed by a maintained high level until now. Our study, for the first time, provides an estimated timescale for the HBV/C epidemic, and brings new insight to the dispersal of HBV/C in humans globally. Based on the continuous presence of a highly effective viral population, this study provides further evidence of the challenge from a population-based molecular level to eliminate HBV by 2030, and calls for a concerted effort from policy makers, health providers, and society in the globalized world.

Keywords: HBV genotype C; Hepatitis B virus; evolution; phylogenetic; phylogeographic.

StephenW

https://www.jstage.jst.go.jp/art ... pub_2022.01030/_pdf