亚洲和非洲高或中流行区献血者的乙型肝炎病毒慢性感染：

StephenW

亚洲和非洲高或中流行区献血者的乙型肝炎病毒慢性感染：按性别进行比较
让-皮埃尔·阿兰
1,*, 雪莉·奥乌苏-奥弗里
2、叶贤林
3、西里尔·比塞耶
4 [ORCID]，米拉埃尔查尔
5【ORCID】和李承耀
6
1
剑桥大学血液学系，剑桥 CB1 8RN，英国
2
Komfo Anokye 教学医院输血医学科，库马西 P.O. Box 1934，加纳
3
深圳血液中心,深圳 518000
4
马苏库科技大学科学学院生物系，弗朗西维尔 P.O. Box 943, 加蓬
5
巴拉曼大学健康科学学院，P.O. Box 166378 Ashrafieh, 贝鲁特 1100-2807, 黎巴嫩
6
南方医科大学检验医学与生物技术学院输血医学系, 广州 510515
*
通讯作者。
学术编辑：米格尔·A·马丁内斯
病毒 2022, 14(4), 673; https://doi.org/10.3390/v14040673
收到日期：2022 年 2 月 9 日 / 修订日期：2022 年 3 月 16 日 / 接受日期：2022 年 3 月 21 日 / 发布日期：2022 年 3 月 24 日
（这篇文章属于特刊 HIV-1 和肝炎病毒合并感染）
查看全文 下载 PDF 浏览图
审阅报告引文导出
抽象的
对各种传染病，特别是病毒的免疫控制，对女性来说比男性更有效。女性对病毒疫苗（HAV、HBV）的反应较高。 15 年来在献血者中积累的乙型肝炎病毒 (HBV) 标志物数据按性别分层，包括基因型 B 和 C（中国）、基因型 D（伊朗、黎巴嫩、突尼斯）和基因型 E（加纳、布基纳法索、加蓬）流行。 HBsAg 通过 ELISA 或快速测试筛选，抗-HBc 和抗-HBs 通过 ELISA 筛选，HBV DNA 载量通过跨站点的标准化方法筛选。在 5 岁以下的加纳儿童中，女性的 HBV DNA 载量显着低于男性（p = 0.035）。在中国、加纳、布基纳法索和加蓬的献血者中，HBsAg 中位患病率在中国分别为 ~5% 和 3%，在加蓬分别为 ~8.5% 和 4.5%，在布基纳法索分别为 ~16% 和 11%，在 ~11% 和 7%在加纳，男性和女性捐赠者分别为 (p < 0.001)。在 HBsAg+ 加纳献血者中，性别之间的分布和病毒载量中值没有显着差异；隐匿性乙型肝炎感染（OBI）在男性中更为常见。在中国献血者 anti-HBc+ 和 anti-HBs+ 中，男性的 anti-HBs 水平往往较高，但仅接种了献血者的 anti-HBs+，而 anti-HBs 水平女性>男性。在基因型 B-E 占主导地位的地区，慢性 HBV 感染 (HBsAg+) 的患病率似乎在 16-18 岁之前由垂直或水平感染的女性更好地控制。 OBI 在男性中出现的频率要高得多，这表明 HBV 感染控制的效果较低。女性献血者似乎比男性更安全，因此应该鼓励她们献血。查看全文
关键词：乙肝；献血者；乙肝表面抗原；病毒载量；抗-HBs

StephenW

Hepatitis B Virus Chronic Infection in Blood Donors from Asian and African High or Medium Prevalence Areas: Comparison According to Sex
by Jean-Pierre Allain
1,*, Shirley Owusu-Ofori
2, Xianlin Ye
3, Cyrille Bisseye
4 [ORCID] , Mira El Chaar
5 [ORCID] and Chengyao Li
6
1
Department of Hematology, University of Cambridge, Cambridge CB1 8RN, UK
2
Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi P.O. Box 1934, Ghana
3
Shenzhen Blood Centre, Shenzhen 518000, China
4
Department of Biology, Faculty of Sciences, University of Science and Technology of Masuku, Franceville P.O. Box 943, Gabon
5
Faculty of Health Sciences, University of Balamand, P.O. Box 166378 Ashrafieh, Beirut 1100-2807, Lebanon
6
Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China
*
Author to whom correspondence should be addressed.
Academic Editor: Miguel A. Martínez
Viruses 2022, 14(4), 673; https://doi.org/10.3390/v14040673
Received: 9 February 2022 / Revised: 16 March 2022 / Accepted: 21 March 2022 / Published: 24 March 2022
(This article belongs to the Special Issue HIV-1 and Hepatitis Virus Co-infection)
View Full-Text Download PDF Browse Figures
Review Reports Citation Export
Abstract
Immune control of various infectious diseases, particularly viral, was shown to be more efficient for females than males. Response to viral vaccines (HAV, HBV) was higher in females. Data on hepatitis B virus (HBV) markers accumulated over 15 years in blood donors was stratified according to sex, including HBsAg, HBV viral load and levels of anti-HBs in areas where genotypes B and C (China), genotype D (Iran, Lebanon, Tunisia) and genotype E (Ghana, Burkina Faso, Gabon) were prevalent. HBsAg was screened by either ELISA or rapid tests, anti-HBc and anti-HBs by ELISA, HBV DNA load by a standardized method across sites. In Ghanaian children less than 5 years, HBV DNA load was significantly lower in females than in males (p = 0.035). In China, Ghana, Burkina Faso and Gabon blood donors, median HBsAg prevalence was ~5% and 3% in China, ~8.5% and 4.5% in Gabon, ~16% and 11% in Burkina Faso and ~11% and 7% in Ghana for male and female donors, respectively (p < 0.001). In HBsAg+ Ghanaian blood donors, distribution and median viral load were not significantly different between sexes; occult hepatitis B infections (OBI) were significantly more frequent in males. In Chinese blood donor anti-HBc+ and anti-HBs+, anti-HBs levels tended to be higher in males but vaccinated donors’ anti-HBs+ only, while anti-HBs levels were females > males. In areas where genotypes B-E are dominant, the prevalence of chronic HBV infection (HBsAg+) seems better controlled before age 16–18 by females infected vertically or horizontally. OBIs appear considerably more frequent in men, suggesting lower efficacy of HBV infection control. Female blood donors appear significantly safer from HBV than males, and their donation should be encouraged. View Full-Text
Keywords: HBV; blood donors; HBsAg; viral load; anti-HBs

StephenW

https://www.mdpi.com/1999-4915/14/4/673/pdf