常溫機器灌注是肝移植的“遊戲規則改變者”

StephenW

常溫機器灌注是肝移植的“遊戲規則改變者”

最初由我們的姊妹刊物《普通外科新聞》發表

在一項新研究中，使用常溫機器灌注可以移植大約 70% 被認為不適合移植的肝臟。在中央外科協會/中西部外科協會聯合年會上發表的研究結果（摘要 20）來自對 21 個被指定丟棄的人類肝臟的研究。

根據主要研究作者、俄亥俄州克利夫蘭診所肝臟移植項目主任、醫學博士克里斯蒂亞諾·昆蒂尼 (Cristiano Quintini) 的說法，這是美國首次評估常溫機器灌注 (NMP) 用於廢棄肝臟的臨床試驗，其目標是肝移植。 “器官供需仍然存在巨大差異。仍有 15% 到 20% 的肝移植候補名單上的患者永遠不會獲得器官，並且會在候補名單上死亡，”Quintini 博士說。 “常溫機器灌注是器官移植領域的遊戲規則改變者。”

NMP是一種器官保存方法，在器官保存過程中提供氧氣和營養，並允許有氧代謝。 Quintini 博士說：“這台機器允許肝臟在接近生理條件下保持在體外，類似於在體內發現的情況，在體溫下將含氧血液泵入器官。” “我告訴病人，我們在保存期間保持器官存活，因為沒有更好的術語，而不是保持器官在冰上並將其冷卻到接近冰點的溫度（就像移植中通常所做的那樣）。”

StephenW

Normothermic Machine Perfusion a ‘Game-Changer’ For Liver Transplants

Originally published by our sister publication, General Surgery News

In a new study, the use of normothermic machine perfusion allowed the transplantation of roughly 70% of livers that were deemed unfit for transplant. The findings, presented at the joint annual meeting of the Central Surgical Association/Midwest Surgical Association (abstract 20), come from a study of 21 humans livers designated to be discarded.

According to lead study author Cristiano Quintini, MD, the director of the Liver Transplant Program at the Cleveland Clinic in Ohio, this is the first clinical trial in the United States to evaluate normothermic machine perfusion (NMP) for use on discarded livers with the goal of liver transplantation. “There continues to be a huge discrepancy in the organ supply and demand. There are still 15% to 20% of patients that are on the liver transplant waitlist that will never be offered an organ and will die on the waiting list,” said Dr. Quintini. “Normothermic machine perfusion is a game-changer in the field of organ transplantation.”

NMP is a method of organ preservation that provides oxygen and nutrition during organ preservation and allows aerobic metabolism. “The machine allows livers to be kept outside of the body in near-physiological conditions, similar to those found in the body, with oxygenated blood that is pumped at body temperature through the organ,” said Dr. Quintini. “I tell the patient that we maintain the organ alive, for lack of a better term, during the preservation time, as opposed to maintaining the organ on ice and cooling it down to near freezing temperatures [as is usually done in transplants].”

StephenW

https://www.gastroendonews.com/W ... mp;utm_medium=title