與急性乙型肝炎患者相比，慢性乙型肝炎患者與肝損傷相關

StephenW

與急性乙型肝炎患者相比，慢性乙型肝炎患者與肝損傷相關的炎症細胞因子譜更廣泛、更強 Get access Arrow
亞歷山德拉·約翰遜·瓦連特、林健生、凱瑟琳·B·施瓦茨、菲利普·羅森塔爾、凱倫·F·默里、道格拉斯·莫古爾、杰弗裡·泰克曼、諾貝托·羅德里格茲-貝茲、莎拉·簡·施瓦岑貝格、喬丹·J·費爾德、大衛·K·王、利亞·L·劉易斯-希門尼斯、喬治·勞爾, Bettina E Hansen, Simon C Ling, Harry LA Janssen, Adam J Gehring
《傳染病雜誌》，第 225 卷，第 3 期，2022 年 2 月 1 日，第 470–475 頁，https://doi.org/10.1093/infdis/jiab373
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2021 年 7 月 21 日
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抽象的

乙型肝炎的肝損傷是免疫驅動的，並且與患者血清中的炎症標誌物相關。沒有比較這些標誌物來確定炎症特徵是否與處於不同疾病階段的患者的不同類型的肝損傷不同。我們測量了急性乙型肝炎和慢性乙型肝炎患者乙型肝炎 e 抗原血清轉換和停止核苷類似物治療的慢性患者的 25 種炎症標誌物。骨髓標誌物在乙型肝炎所有階段的炎症特徵中占主導地位。在慢性患者中可檢測到更多炎症標誌物，包括細胞毒性效應物 Fas 配體、TRAIL 和 TNF-α 濃度升高。
炎症、生物標誌物、免疫反應、耀斑、乙型肝炎、HBV、血漿、細胞因子、趨化因子
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    細胞因子 腫瘤壞死因子 炎症標誌物 炎症趨化因子 乙型肝炎 e 抗原 乙型肝炎、慢性血漿 乙型肝炎病毒 肝損傷 核苷類似物 腫瘤壞死因子配體 超家族成員 6 急性乙型病毒性肝炎血清轉換

StephenW

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B Get access Arrow
Alexandra Johnson Valiente, Kin Seng Liem, Kathleen B Schwarz, Philip Rosenthal, Karen F Murray, Douglas Mogul, Jeffery Teckman, Norberto Rodriguez-Baez, Sarah Jane Schwarzenberg, Jordan J Feld, David K Wong, Lia L Lewis-Ximenez, Georg Lauer, Bettina E Hansen, Simon C Ling, Harry L A Janssen, Adam J Gehring
The Journal of Infectious Diseases, Volume 225, Issue 3, 1 February 2022, Pages 470–475, https://doi.org/10.1093/infdis/jiab373
Published:
21 July 2021
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Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.
inflammation, biomarker, immune response, flare, hepatitis B, HBV, plasma, cytokines, chemokines
Topic:

    cytokine tumor necrosis factors inflammatory markers inflammation chemokines hepatitis b hepatitis b e antigens hepatitis b, chronic plasma hepatitis b virus liver damage nucleoside analog tumor necrosis factor ligand superfamily member 6 acute type b viral hepatitis seroconversion