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Estimated Prevalence and Number of Persons With Isolated Antibody to Hepatitis B Core Antigen and Associated Occult Hepatitis B, United States, 2001–2018
Philip R Spradling, Jian Xing, Aaron M Harris, Kathleen N Ly
The Journal of Infectious Diseases, Volume 225, Issue 3, 1 February 2022, Pages 465–469, https://doi.org/10.1093/infdis/jiab366
Published:
12 July 2021
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Abstract
Persons with isolated antibody to hepatits B virus (HBV) core antigen (IAHBc) may have occult HBV infection (OBI), which is associated with reactivation and potential risk for hepatocellular carcinoma and HBV transmission. We used National Health and Nutrition Examination Survey data to estimate US IAHBc prevalence and published studies of IAHBc-associated OBI prevalence to estimate OBI burden. During 2001−2018, the prevalence of IAHBc was 0.8% (approximately 2.1 million persons), and the OBI burden range was 35 500–83 600 persons. These data support the need for more robust estimates of IAHBc-associated OBI prevalence in the general US population.
isolated hepatitis B core antibody, occult hepatitis B, prevalence
Topic:
hepatitis b antigens hepatitis b virus national health and nutrition examination survey hepatitis b core antibody
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