聚乙二醇化干扰素-ɑ (IFN-ɑ) 在慢性乙型肝炎中通过 IFN-γ

StephenW

聚乙二醇化干扰素-ɑ (IFN-ɑ) 在慢性乙型肝炎中通过 IFN-γ 增强自然杀伤细胞对调节性 T 细胞的抑制作用
魏源、大黄、吴迪、陈玉英、马柯、韩美芳、罗小平、颜伟明、秦宁
《传染病杂志》，第 224 卷，第 11 期，2021 年 12 月 1 日，第 1878-1889 页，https://doi.org/10.1093/infdis/jiab216
发表：
2021 年 4 月 19 日
文章历史

    引用
    权限图标权限
    分享

抽象的

最近已经认识到自然杀伤 (NK) 细胞的免疫调节作用，但其在慢性乙型肝炎 (CHB) 感染和治疗过程中对 CD4+CD25+ 调节性 T 细胞 (Tregs) 的影响仍不清楚。总共包括 116 名接受核苷（酸）苷类似物 (NA) 治疗的 CHB 患者。在基于聚乙二醇化干扰素-ɑ (PegIFN-ɑ) 治疗的 NA 抑制患者中发现 NK 细胞和 Tregs 的外周频率之间呈负相关。此外，NK 细胞通过分泌 IFN-γ 抑制 Tregs 的增殖和分化，这在 NA 治疗的 CHB 患者的循环以及 HBV 携带小鼠模型的肝脏中得到了证明。此外，PegIFN-ɑ 治疗可以增强抑制作用，这与更强烈的 HBV 特异性 T 细胞反应和 HBsAg 的显着降低相关。我们的研究揭示了 NK 细胞的新免疫调节机制，并为 PegIFN-ɑ 作为治疗 CHB 患者的免疫治疗剂提供了理论基础。
自然杀伤细胞、调节性 T 细胞、免疫调节、IFN-γ、慢性乙型肝炎
话题：

    乙型肝炎，慢性干扰素自然杀伤细胞 T 淋巴细胞 乙型肝炎病毒人类白细胞干扰素调节性 T 淋巴细胞

StephenW

Pegylated Interferon-ɑ (IFN-ɑ) Enhances the Inhibitory Effect of Natural Killer Cells on Regulatory T Cells via IFN-γ in Chronic Hepatitis B
Wei Yuan, Da Huang, Di Wu, Yuying Chen, Ke Ma, Meifang Han, Xiaoping Luo, Weiming Yan, Qin Ning
The Journal of Infectious Diseases, Volume 224, Issue 11, 1 December 2021, Pages 1878–1889, https://doi.org/10.1093/infdis/jiab216
Published:
19 April 2021
Article history

    Cite
    Permissions Icon Permissions
    Share

Abstract

The immunomodulatory role of natural killer (NK) cells has been recognized recently, but its effects on CD4+CD25+ regulatory T cells (Tregs) during chronic hepatitis B (CHB) infection and treatment remain unclear. A total of 116 nucleos(t)ide analogue (NA)-treated CHB patients were included. An inverse correlation between the peripheral frequencies of NK cells and Tregs was found in NA suppressed patients following pegylated interferon-ɑ (PegIFN-ɑ)–based treatment. Furthermore, NK cells suppressed the proliferation and differentiation of Tregs through secreting IFN-γ as was evidenced in the circulation of NA-treated CHB patients as well as in liver of HBV-carrier mouse model. Additionally, the inhibition could be enhanced by PegIFN-ɑ treatment, which was correlated to more vigorous HBV-specific T-cell responses and marked reduction in HBsAg. Our study reveals a novel immunomodulatory mechanism of NK cells and provides a theoretical basis for PegIFN-ɑ as an immunotherapy agent in treating patients with CHB.
natural killer cells, regulatory T cells, immune regulation, IFN-γ, chronic hepatitis B
Topic:

    hepatitis b, chronic interferons natural killer cells t-lymphocytes hepatitis b virus human leukocyte interferon regulatory t-lymphocytes