乙肝表面抗原阳性母亲所生婴儿接种疫苗后血清学检测的最

StephenW

乙肝表面抗原阳性母亲所生婴儿接种疫苗后血清学检测的最佳间隔时间
黄宏宇 1 2 , 张旭辉 3 , 罗玉倩 2 , 陈洁 4 , 景峰 4 , 戴益民 4 , 胡亚丽 4 , 周奕华 2 5
隶属关系
隶属关系

    1
    【作者单位】： 江苏省无锡市苏州大学附属无锡市第九人民医院感染科;
    2
    【作者单位】： 江苏省南京市南京大学医学院附属南京鼓楼医院检验科;
    3
    无锡市疾病预防控制中心环境卫生司，江苏省无锡市。
    4
    南京大学医学院附属南京鼓楼医院妇产科，江苏南京。
    5
    南京大学医学院附属南京鼓楼医院感染科，江苏南京

    PMID：34736352 DOI：10.1080/21645515.2021.1992213

抽象的

疫苗接种后血清学检测 (PVST) 用于监测乙型肝炎表面抗原 (HBsAg) 阳性母亲的婴儿接种乙型肝炎病毒 (HBV) 感染疫苗的成功与否。这项对 7-14 个月大 HBsAg 阳性母亲的 1255 名婴儿进行的二次分析纳入了两项前瞻性研究，旨在确定三剂乙型肝炎疫苗接种后 PVST 的最佳间隔。 HBsAg和抗-HBs用微粒酶免疫法定量检测。平均 PVST 间隔为 3.8 ± 2.2 个月。总体而言，1.7% (21/1255) 婴儿的抗 HBs <10 mIU/mL。在间隔 1、2、3、4、5、6 和 7 进行 PVST 时，无反应率为 1.6%、1.1%、0.9%、0.7%、1.1%、0.7% 和 5.7%分别在第三剂疫苗接种后 8 个月。与1个月的PVST间隔相比，接受PVST 7-8个月的婴儿的无反应率显着更高（χ2 = 4.616，P = .032）。当 PVST 间隔较长时，中等反应婴儿的抗 HBs 滴度显着下降（χ2 = 27.592，P < .001），实际上从 6 个月和 7-8 个月的间隔开始下降（Z = -3.177，P = .001 和 Z = -3.715，P < .001)，分别。这些结果表明，对于按 0、1 和 6 个月的时间表接种疫苗的婴儿，可以在 7-12 个月大时进行 PVST。为了尽早识别无反应者，我们建议在 7 个月大或最后一次疫苗接种后 1 个月进行 PVST。

关键词：HBsAg 阳性母亲；乙型肝炎疫苗； PVST间隔；抗-HBs；婴儿；无反应率。

StephenW

The optimal interval for post-vaccination serological test in infants born to mothers with positive hepatitis B surface antigen
Hongyu Huang  1   2 , Xuhui Zhang  3 , Yuqian Luo  2 , Jie Chen  4 , Jing Feng  4 , Yimin Dai  4 , Yali Hu  4 , Yi-Hua Zhou  2   5
Affiliations
Affiliations

    1
    Department of Infection Management, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
    2
    Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
    3
    Department of Environmental Health, Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China.
    4
    Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.
    5
    Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.

    PMID: 34736352 DOI: 10.1080/21645515.2021.1992213

Abstract

Postvaccination serologic testing (PVST) is utilized to monitor the success or failure of vaccination against hepatitis B virus (HBV) infection in infants of hepatitis B surface antigen (HBsAg) positive mothers. This secondary analysis of 1255 infants of HBsAg-positive mothers at 7-14 months age included in two prospective studies aimed to determine the optimal interval for PVST after three hepatitis B vaccine doses. HBsAg and anti-HBs were quantitatively tested with microparticle enzyme immunoassay. The average PVST interval was 3.8 ± 2.2 months. Overall, 1.7% (21/1255) infants had anti-HBs <10 mIU/mL. The non-response rates were 1.6%, 1.1%, 0.9%, 0.7%, 1.1%, 0.7%, and 5.7% when PVST was performed at an interval of 1, 2, 3, 4, 5, 6, and 7-8 months after the third vaccine dose, respectively. Compared with 1 month of PVST interval, the non-response rate in infants who underwent PVST 7-8 months was significantly higher (χ2 = 4.616, P = .032). Anti-HBs titers were significantly declined in infants with medium responses when PVST was performed with longer intervals (χ2 = 27.592, P < .001), actually declined from interval of 6, and 7-8 months (Z = -3.177, P = .001 and Z = -3.715, P < .001), respectively. These results indicate that PVST may be performed at the age of 7-12 months for infants vaccinated on 0, 1, and 6-month schedule. To identify non-responders as early as possible, we suggest that PVST is performed at 7 months age or 1 month after the final vaccine dose.

Keywords: HBsAg-positive mothers; Hepatitis B vaccine; PVST interval; anti-HBs; infants; non-response rate.