Sirtuins 作为乙型肝炎病毒感染的潜在治疗靶点

StephenW

Sirtuins 作为乙型肝炎病毒感染的潜在治疗靶点
孔繁云1 , 齐力1 2 , 张福龙3 , 小翠丽1 , 红娟友1 , 潘秀成4 , 夔阳政1 5 , 任贤汤1 5
隶属关系
隶属关系

    1
    徐州医科大学病原生物学与免疫学系江苏省免疫与代谢重点实验室，中国徐州。
    2
    【作者单位】： 盐城市阜宁市人民医院检验科;
    3
    山东第一医科大学第二附属医院影像科，中国泰安。
    4
    徐州医科大学附属医院感染科，中国徐州。
    5
    徐州医科大学国家实验基础医学教育示范中心，中国徐州。

    PMID：34708060 PMCID：PMC8542665 DOI：10.3389/fmed.2021.751516

抽象的

Sirtuins (SIRTs) 是众所周知的组蛋白去乙酰化酶，能够调节多种疾病中的各种细胞过程，包括乙型肝炎病毒 (HBV) 的感染，乙型肝炎病毒 (HBV) 是肝硬化和肝细胞癌的主要致病驱动因素之一。越来越多的证据表明，HBV 可以改变所有 SIRT 蛋白的表达水平。反过来，所有 SIRT 都通过一系列分子机制调节 HBV 复制。此外，一些研究表明，使用合适的药物靶向 SIRT 是 HBV 感染的潜在治疗策略。在这里，我们讨论了与 SIRT 介导的病毒传播上调相关的分子机制，以及作为针对 HBV 感染的潜在治疗方式的 SIRT 靶向治疗的最新进展。

关键词：HBV感染； HBx;分子机制；沉默；治疗。

版权所有 © 2021 Kong, Li, Zhang, Li, You, Pan, Zheng and Tang。

StephenW

   Sirtuins as Potential Therapeutic Targets for Hepatitis B Virus Infection
Fanyun Kong  1 , Qi Li  1   2 , Fulong Zhang  3 , Xiaocui Li  1 , Hongjuan You  1 , Xiucheng Pan  4 , Kuiyang Zheng  1   5 , Renxian Tang  1   5
Affiliations
Affiliations

    1
    Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, China.
    2
    Laboratory Department, The People's Hospital of Funing, Yancheng, China.
    3
    Imaging Department, The Second Affiliated Hospital of Shandong First Medical University, Taian, China.
    4
    Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
    5
    National Demonstration Center for Experimental Basic Medical Sciences Education, Xuzhou Medical University, Xuzhou, China.

    PMID: 34708060 PMCID: PMC8542665 DOI: 10.3389/fmed.2021.751516

Abstract

Sirtuins (SIRTs) are well-known histone deacetylases that are capable of modulating various cellular processes in numerous diseases, including the infection of hepatitis B virus (HBV), which is one of the primary pathogenic drivers of liver cirrhosis and hepatocellular carcinoma. Mounting evidence reveals that HBV can alter the expression levels of all SIRT proteins. In turn, all SIRTs regulate HBV replication via a cascade of molecular mechanisms. Furthermore, several studies suggest that targeting SIRTs using suitable drugs is a potential treatment strategy for HBV infection. Here, we discuss the molecular mechanisms associated with SIRT-mediated upregulation of viral propagation and the recent advances in SIRT-targeted therapy as potential therapeutic modalities against HBV infection.

Keywords: HBV infection; HBx; molecular mechanisms; sirtuins; therapy.

Copyright © 2021 Kong, Li, Zhang, Li, You, Pan, Zheng and Tang.

StephenW

https://www.frontiersin.org/articles/10.3389/fmed.2021.751516/pdf