日本非活动性乙型肝炎病毒携带者的死亡率与一般人群相似

StephenW

日本非活动性乙型肝炎病毒携带者的死亡率与一般人群相似
Takashi Kumada 1 , Hidenori Toyoda 2 , Satoshi Yasuda 2 , Takanori Ito 3 , Junko Tanaka 4
隶属关系
隶属关系

    1
    日本岐阜县大垣市岐阜共立大学护理学院护理系。
    2
    日本岐阜县大垣市大垣市立医院消化内科和肝病科。
    3
    日本名古屋名古屋大学医学研究生院胃肠病学和肝病学系。
    4
    日本广岛广岛大学生物医学与健康科学研究所流行病学、传染病控制和预防系。

    PMID：34665918 DOI：10.1111/hepr.13723

抽象的

目的：由于数量少，关于乙型肝炎病毒 (HBV) 感染者为肝炎包膜抗原 (HBeAg) 阴性非活性携带者 (IC) 的长期结果数据有限。我们比较了定义明确的 IC 与年龄和性别匹配的一般人群对照的长期预后。

方法：共纳入 526 例 HBeAg 阴性患者，这些患者在随访开始后 1 年内至少 3 次表现出丙氨酸氨基转移酶（ALT）水平≤ 40 U/L 和 HBV DNA 水平≤ 4.3 log IU/mL。集成电路。 IC 分为 2 组：A 组（n=332），ALT 水平≤30 U/L，HBV DNA 水平≤3.3 log IU/mL，B 组（剩余患者，n=194）。我们确定了 IC 的长期预后，并将其与一般人群对照的长期预后进行了比较。我们还分析了与 IC 中乙型肝炎表面抗原 (HBsAg) 清除和相变相关的因素。

结果：A 组和 B 组之间的肝细胞癌发展或全因、肝脏相关或非肝脏相关死亡率没有显着差异。IC 和一般人群之间的全因死亡率没有显着差异。低 HBsAg 水平（≤ 3.0 log IU/mL）和脂肪肝的存在与 HBsAg 清除相关，而高甲胎蛋白水平与相变相关。

结论：明确定义的 IC 的长期预后与一般人群对照相似。此外，ICs 具有高 HBsAg 清除率和低相变率。 (243 字) 本文受版权保护。版权所有。

关键词：HBV DNA；总人口;乙型肝炎病毒（HBV）；肝炎包膜抗原 (HBeAg);非活动载体；受限平均生存时间 (RMST)。

本文受版权保护。版权所有。

StephenW

Mortality of inactive hepatitis B virus carriers in Japan is similar to that of the general population
Takashi Kumada  1 , Hidenori Toyoda  2 , Satoshi Yasuda  2 , Takanori Ito  3 , Junko Tanaka  4
Affiliations
Affiliations

    1
    Department of Nursing, Faculty of Nursing, Gifu Kyoritsu University, Ogaki, Gifu, Japan.
    2
    Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan.
    3
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    4
    Department of Epidemiology, Infectious Disease Control, and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan.

    PMID: 34665918 DOI: 10.1111/hepr.13723

Abstract

Aims: Data on the long-term outcomes of individuals with hepatitis B virus (HBV) infection who are hepatitis envelope antigen (HBeAg)-negative inactive carriers (ICs) are limited due to small numbers. We compared the long-term prognosis of well-defined ICs with that of age- and gender-matched general population controls.

Methods: A total of 526 HBeAg-negative patients who demonstrated alanine aminotransferase (ALT) level ≤ 40 U/L and HBV DNA level ≤ 4.3 log IU/mL at least 3 times within 1 year after the start of follow-up were enrolled as ICs. ICs were divided into 2 groups: Group A (n=332), whose ALT level was ≤ 30 U/L and HBV DNA level was ≤ 3.3 log IU/mL, and Group B (remaining patients, n=194). We determined the long-term prognosis of ICs and compared it with that of general population controls. We also analyzed factors associated with hepatitis B surface antigen (HBsAg) clearance and phase transition in ICs.

Results: There were no significant differences in hepatocellular carcinoma development or all-cause, liver-related, or non-liver-related mortality between Groups A and B. There was no significant difference in all-cause mortality between ICs and the general population. Low HBsAg level (≤ 3.0 log IU/mL) and the presence of fatty liver were associated with HBsAg clearance and high alpha-fetoprotein level was associated with phase transition.

Conclusions: The long-term prognosis of well-defined ICs was similar to that of general population controls. In addition, the ICs had a high HBsAg clearance rate and low phase transition rate. (243 words) This article is protected by copyright. All rights reserved.

Keywords: HBV DNA; general population; hepatitis B virus (HBV); hepatitis envelope antigen (HBeAg); inactive carrier; restricted mean survival time (RMST).

This article is protected by copyright. All rights reserved.