喝超过 3 杯咖啡但不喝其他饮料的受试者 kPa 降低 0.9（95% CI -

StephenW

喝超过 3 杯咖啡但不喝其他饮料的受试者 kPa 降低 0.9（95% CI -1.6 – -0.1，p = 0.03）。
喝咖啡与降低肝脏硬度有关：一项全国代表性的研究
2021 年 10 月 5 日
抽象的
背景
咖啡与降低患肝病的风险有关。这种关联受到重要混杂来源的限制，例如回忆偏差、健康用户偏差和肝脏结果或健康的间接测量。我们的目的是在一个具有全国代表性的样本中检查咖啡消费对肝纤维化和脂肪变性的影响。
方法
我们评估了 2017-2018 年 NHANES 研究中 4,510 名 >20 岁的受试者，这些受试者接受了瞬时弹性成像和两次 24 小时饮食回忆检查。我们测试了肝脏硬度测量值 (LSM) > 9.5 kpa 或受控衰减参数 (CAP) 与咖啡消耗量之间的关联。我们使用不含咖啡因的咖啡和茶作为对照。作为敏感性分析，我们将所有饮料都包括在一个模型中，检查了咖啡因消费的影响，并针对 2015 年健康饮食指数 (HEI-2015) 和含糖饮料消费作为单独的模型进行了调整。
结果
所描述的研究样本年龄为 48 + 0.6 岁，73% 超重或肥胖，10.6% 患有糖尿病，47.5% 报告参与剧烈的体育活动，23% 每天饮用 > 2 杯酒精饮料。多变量调整后，咖啡和对照与 CAP 之间没有关联。喝超过 3 杯咖啡但不喝其他饮料的受试者 kPa 降低 0.9（95% CI -1.6 – -0.1，p = 0.03）。 > 3 杯咖啡对 LSM > 9.5 kpa 具有保护作用（OR：0.4，95% CI 0.2 - 1.0，p = 0.05）。考虑到同一模型中的所有饮料，只有 >3 杯咖啡仍与 LSM 独立相关（OR：0.5，95% CI 0.2 - 0.9，p = 0-03）。在任何剂量下，咖啡因都与 LSM 没有显着相关性。最后，调整含糖饮料消费和 HEI-2015，咖啡消费仍然与较低的 LSM 相关。因此，咖啡消费的保护性质不能归因于咖啡因，并且无论参与者的饮食质量如何，它们都会持续存在。
结论
根据美国成年人的 CAP 测量，咖啡与较低的肝脏硬度有关，但与脂肪变性无关。

StephenW

Subjects who drank >3 cups of coffee, but not other drinks, had 0.9 lower kPa (95% CI -1.6 – -0.1, p = 0.03).
Coffee consumption is associated with lower liver stiffness: a nationally representative study
October 05, 2021
Abstract
Background
Coffee is associated with a reduced risk of liver disease. This association is limited by important sources of confounding such as recall bias, healthy-user bias, and indirect measures of liver outcomes or health. We aimed to examine the impact of coffee consumption with liver fibrosis and steatosis in a nationally representative sample.
Methods
We evaluated 4,510 subjects >20 years old from the 2017-2018 NHANES study that underwent both transient elastography and two 24-hour dietary recall examinations. We tested the associations between liver stiffness measurements (LSM) > 9.5 kpa or controlled attenuation parameter (CAP) and coffee consumption. We used decaffeinated coffee and tea consumption as controls. As sensitivity analysis, we included all drinks in one model, examined the impact of caffeine consumption, and adjusted for the Healthy Eating Index-2015 (HEI-2015) and sugar-sweetened beverage consumption as separate models.
Results
The study sample described was aged 48 + 0.6 years, 73% were overweight or obese, 10.6% had diabetes, 47.5% reported participation in vigorous physical activity, and 23% drank > 2 alcoholic drinks per day. After multivariate adjustment, there was no association between coffee and controls with CAP. Subjects who drank >3 cups of coffee, but not other drinks, had 0.9 lower kPa (95% CI -1.6 – -0.1, p = 0.03). >3 cups of coffee were protective for LSM > 9.5 kpa (OR: 0.4, 95% CI 0.2 - 1.0, p = 0.05). Accounting for all beverages in the same model, only >3 cups of coffee remained independently associated with LSM (OR: 0.5, 95% CI 0.2 - 0.9, p= 0-03). Caffeine was not significantly associated with LSM at any dose. Finally, adjusting for sugar-sweetened beverage consumption and HEI-2015, coffee consumption remained associated with lower LSM. The protective nature of coffee consumption is therefore not attributable to caffeine and persists in participants regardless of their diet quality.
Conclusion
Coffee is associated with lower liver stiffness but not steatosis as measured by CAP among US adults.