HBsAg和HBsAb共阳性患者血清乙型肝炎病毒RNA水平及其与HBV DNA的

StephenW

Analysis of serum hepatitis B virus RNA levels among HBsAg and HBsAb copositive patients and its correlation with HBV DNA
Yu Xiang  1 , Yang Yang  1 , Pu Chen  1 , Xiaofei Lai  1 , Shan Shi  1 , Shuang Li  2 , Wenxian You  3
Affiliations
Affiliations

    1
    Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    2
    Department of General Surgery, Jinshan Hospital, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    3
    Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

    PMID: 34622857 DOI: 10.1097/MD.0000000000027433

Abstract

There are approximately 2 billion HBV-infected individuals worldwide, and approximately 1.87% to 7% of these individuals are copositive for HBsAg and HBsAb.Our study detected hepatitis B virus pgRNA (HBV RNA) levels in HBsAg and HBsAb copositive patients and then analyzed the correlation with HBV DNA, HBsAg, ALT, and AST levels. A total of 149 HBsAg and HBsAb copositive patients were identified from 66,617 outpatients.HBV RNA, HBV DNA, HBsAg, ALT, and AST serum levels were significantly different in different natural phases of HBV infection (immune tolerance phase, immune clearance phase, low replication phase, and reactivation phase) with statistical significance (P < .01). HBV RNA levels were positively correlated with HBV DNA, HBsAg, ALT, and AST levels. HBV RNA and HBV DNA levels were significantly increased in the HBeAg-positive group (66 patients) compared with the HBeAg-negative group (83 patients) (P < .01). In the HBeAg-positive group, HBV RNA levels were positively correlated with HBV DNA and HBsAg levels. In the HBeAg-negative group, HBV RNA levels were positively correlated with HBV DNA. Serum HBV RNA levels were positively correlated with HBV DNA, HBsAg, ALT, and AST levels.HBV RNA could be used as a virological indicator for antiviral therapy in HBsAg and HBsAb copositive hepatitis B patients.

Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

StephenW

HBsAg和HBsAb共阳性患者血清乙型肝炎病毒RNA水平及其与HBV DNA的相关性分析
于翔1、杨洋1、朴晨1、赖小飞1、山实1、双丽2、文先友3
隶属关系
隶属关系

    1
    重庆医科大学第一附属医院检验科，重庆，中国。
    2
    【作者单位】： 重庆医科大学第一附属医院金山医院普外科;
    3
    重庆医科大学第一附属医院消化内科，重庆，中国。

    PMID：34622857 DOI：10.1097/MD.0000000000027433

抽象的

全球约有 20 亿 HBV 感染者，其中约 1.87% 至 7% 的个体同时存在 HBsAg 和 HBsAb。我们的研究检测了 HBsAg 和 HBsAb 共阳性患者的乙型肝炎病毒 pgRNA (HBV RNA) 水平，然后分析了HBV DNA、HBsAg、ALT 和 AST 水平的相关性。从66617例门诊患者中共鉴定出149例HBsAg和HBsAb共阳性患者。HBV RNA、HBV DNA、HBsAg、ALT和AST血清水平在HBV感染的不同自然阶段（免疫耐受期、免疫清除期、低复制期）存在显着差异。阶段和再激活阶段）具有统计学意义（P < .01）。 HBV RNA水平与HBV DNA、HBsAg、ALT和AST水平呈正相关。与 HBeAg 阴性组（83 名患者）相比，HBeAg 阳性组（66 名患者）的 HBV RNA 和 HBV DNA 水平显着升高（P < .01）。在 HBeAg 阳性组中，HBV RNA 水平与 HBV DNA 和 HBsAg 水平呈正相关。在 HBeAg 阴性组中，HBV RNA 水平与 HBV DNA 呈正相关。血清HBV RNA水平与HBV DNA、HBsAg、ALT、AST水平呈正相关。HBV RNA可作为HBsAg和HBsAb共阳性乙型肝炎患者抗病毒治疗的病毒学指标。

版权所有 © 2021 作者。由 Wolters Kluwer Health, Inc. 出版。

StephenW

https://journals.lww.com/md-jour ... _RNA_levels.31.aspx

StephenW

已有报道在 CHB 感染患者中 HBsAg 和抗 HBs 共存。 多种因素可导致HBsAg与抗HBs共存[17-20]：HBV S区或pre-S区的基因突变导致表面抗原“a”决定簇的免疫原性发生变化； HBV变异株的感染或不同亚型HBV的双重感染或连续感染； 以及长期用药引起的基因突变。 本研究共筛选了 66617 份 HBV 血清学标志物样本，选择 149 份 HBsAg 和 HBsAb 共阳性样本进行分析。

The coexistence of HBsAg and anti-HBs in patients with CHB infection has been reported. Various factors can lead to the coexistence of HBsAgs and anti-HBs[17–20]: genetic mutation in the S or pre-S region of HBV causes a change in the immunogenicity of the “a” determinant of surface antigen; infection of the mutant HBV strain or double infection or successive infection of different subtypes of HBV; and genetic mutation induced by long-term medication. A total of 66,617 samples of HBV serological markers were screened in this study, and 149 that were HBsAg and HBsAb copositive were selected for analysis.