中國健康兒童肝臟硬度和脂肪衰減參數參考範圍的確定

StephenW

中國健康兒童肝臟硬度和脂肪衰減參數參考範圍的確定

曾繁森a,,*;王海燕 b,,*;李旭芳
作者信息

a 廣州醫科大學廣州市婦女兒童醫學中心感染科肝病科

b 中國廣東省廣州市中山大學附屬第一醫院神經內科

*曾繁森和王海燕同等貢獻，共同第一作者。

2020 年 4 月 20 日接收 2020 年 5 月 28 日接受

中國廣東省廣州市金穗路 9 號廣州醫科大學廣州市婦女兒童醫學中心感染科肝病科曾繁森通訊 510515 電話：+86 13560034520；郵箱：[email protected]
歐洲胃腸病學和肝病學雜誌：2021 年 11 月 - 第 33 卷 - 第 11 期 - 第 1394-1399 頁
doi：10.1097/MEG.0000000000001874

  
抽象的
宗旨

我們旨在建立健康中國兒童肝臟硬度和脂肪堆積的基礎參考水平。
方法

為了獲得肝臟硬度測量值 (LSM) 和脂肪衰減參數 (FAP) 水平，瞬態彈性成像 (FibroTouch) 被用於 0 至 18 歲的兒科患者。患者分為以下幾組：新生兒/嬰兒（0-2歲）、學齡前兒童（3-5歲）、小學生（6-11歲）和青少年/青少年（12-18歲）。進行體重、身高和空腹肝功能測試。進行了 FibroTouch 和腹部超聲檢查。
結果

1362 名兒童（329 名男性；中位年齡 4.6 歲；年齡範圍 0.2-17.6 歲）中 521 名的肝臟接受了 FibroTouch 檢查。 LSM 參考範圍為 1.5-5.9 kPa，FAP 參考範圍為 0-18 歲健康兒童的 159.6-217.1 dB/m。男性的 LSM 中值高於女性（分別為 3.5 和 3.2 kPa；P = 0.01）。
結論

華南地區0~18歲健康兒童LSM參考範圍為1.5~5.9 kPa，FAP參考範圍為159.6~217.1 dB/m。 LSM 值在 3 至 18 歲兒童中與年齡相關，而 FAP 值在 0 至 18 歲兒童中與年齡無關。
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StephenW

The defining of the reference range of liver stiffness and fat attenuation parameter for healthy Chinese children

Zeng, Fansen a,,*; Wang, Haiyan b,,*; Li, Xufang a
Author Information

a Hepatology Unit, Department of Infectious Diseases, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University

b Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China

*Fansen Zeng and Haiyan Wang contributed equally and co-first authors.

Received 20 April 2020 Accepted 28 May 2020

Correspondence to Fansen Zeng, Hepatology Unit, Department of Infectious Diseases, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, No. 9 Jinsui Road, Guangzhou City 510515, Guangdong Province, China, Tel: +86 13560034520; e-mail: [email protected]
European Journal of Gastroenterology & Hepatology: November 2021 - Volume 33 - Issue 11 - p 1394-1399
doi: 10.1097/MEG.0000000000001874

  
Abstract
Aims

We aimed to establish the basal reference levels of liver stiffness and accumulated fat in healthy Chinese children.
Methods

To obtain the liver stiffness measurement (LSM) and the fat attenuation parameter (FAP) levels, the transient elastography (FibroTouch) was used in pediatric patients aged 0 to 18 years. The patients were divided into groups as follows: newborns/infants (0–2 years), preschool children (3–5 years), elementary school children (6–11 years), and adolescents/teenagers (12–18 years). The weight, height and fasting liver function tests were performed. FibroTouch and abdominal ultrasonography were performed.
Results

The livers of 521 out of 1362 children (329 male; median age, 4.6 years; age range 0.2–17.6 years) were examined with the FibroTouch. The LSM reference range was 1.5–5.9 kPa, and the FAP reference range was 159.6–217.1 dB/m in healthy children from 0 to 18 years of age. The median LSM value was higher in males than that in females (3.5 vs. 3.2 kPa, respectively; P = 0.01).
Conclusion

For healthy children from 0 to 18 years in southern China, the LSM reference range was 1.5–5.9 kPa, and the FAP reference range was 159.6–217.1 dB/m. The LSM values were age-dependent in children from 3 to 18 years old, and the FAP values were age-independent in children from 0 to18 years old.
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