2015-2020年中国2853个县9000万孕妇乙肝病毒感染情况：一项全国

StephenW

2015-2020年中国2853个县9000万孕妇乙肝病毒感染情况：一项全国观察性研究
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2021 年 9 月 30 日

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Lancet Reg Health West Pac。 2021 年 9 月 5 日；16:100267。 doi：10.1016/j.lanwpc.2021.100267。 eCollection 2021 年 11 月

抽象的

背景：中国是乙型肝炎病毒（hepatitis B virus，HBV）感染疾病负担最大的国家，被认为是到2030年全球消除乙型肝炎的主要推动者。但是，中国孕妇HBV感染的全国流行情况尚未见报道。我们评估了 2015-2020 年中国孕妇 HBV 感染的全国和地区流行情况，旨在提供最新的基线数据。

方法：我们通过对中国孕妇进行的全国性横断面研究收集的数据评估了 HBV 感染的流行率。数据来自中国艾滋病、梅毒和乙型肝炎母婴传播综合防治计划（iPMTCT计划），该计划涵盖了2015年至2020年31个省的2856个县。HBV感染被定义为乙型肝炎表面抗原 (HBsAg) 检测呈血清阳性。

结果：2015年至2020年，中国大陆共有9087万孕妇进行HBV检测，其中560万人（6.17%，95%CI：6.16-6.18%）HBsAg检测呈阳性。从2015年到2020年，孕妇HBV感染率下降了25.44%，从2015年的7.30%下降到2020年的5.44%（趋势p<0.001），估计年度百分比变化（EAPC）为-5.27%（ 95% 置信区间：-3.19% 至 -7.32%）。与2015年相比，东、中、西部地区地区差异缩小。省级和县级也出现下降。 2015 年至 2020 年，大部分省（90.3%，28/31）和县（76.96%，2198/2856）的 HBV 流行率有所下降，但仍存在差异。

解读：中国孕妇HBV流行呈中度流行，2015年至2020年持续下降。下降趋势在各地区普遍存在，但仍存在差异。 HBV 感染疾病负担相对较高的地区在实现 2030 年消除目标方面应受到最大关注。

基金资助：国家自然科学基金。

PMID:34590067 | PMCMC8429967 | DOI:10.1016/j.lanwpc.2021.100267

StephenW

Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study
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September 30, 2021

This article was originally published here

Lancet Reg Health West Pac. 2021 Sep 5;16:100267. doi: 10.1016/j.lanwpc.2021.100267. eCollection 2021 Nov.

ABSTRACT

BACKGROUND: China has the largest disease burden of hepatitis B virus (HBV) infection and is considered as a major contributor to the global elimination of hepatitis B by 2030. However, the national prevalence of HBV infection among Chinese pregnant women was not reported yet. We evaluated the national and regional prevalence of HBV infection among pregnant women in China between 2015-2020, aiming to provide the latest baseline data.

METHODS: We assessed the prevalence of HBV infection from data gathered through a nationwide cross-sectional study of Chinese pregnant women. Data were obtained from the National Integrated Prevention of Mother-to-Child Transmission of HIV, Syphilis and Hepatitis B Programme (iPMTCT Programme) in China, which covered all the 2856 counties from 31 provinces from 2015 to 2020. HBV infection was defined as being tested seropositive for hepatitis B surface antigen (HBsAg).

FINDINGS: A total of 90.87 million pregnant women in mainland China were testing for HBV between 2015 and 2020, with 5.60 million (6.17%, 95%CI: 6.16-6.18%) tested positive for HBsAg. From 2015 to 2020, the prevalence of HBV infection among pregnant women declined by 25.44%, from 7.30% in 2015 to 5.44% in 2020 (p for trend < 0.001), with an estimated annual percentage change (EAPC) of -5.27% (95% CI: -3.19% to -7.32%). Compared with the prevalence in 2015, reginal disparities in eastern, central, and western China were narrowed. Declines were also observed at provincial level and county level. HBV prevalence declined in most provinces (90.3%, 28/31) and counties (76.96%, 2198/2856) from 2015 to 2020. However, disparities still exist.

INTERPRETATION: HBV prevalence in pregnant women in China was intermediate endemic and declined continuously from 2015 to 2020. The decline has been widespread across regions, but disparities remain. Regions with relatively higher disease burden on HBV infection should receive most attention in achieving the 2030 elimination goals.

FUNDING: National Natural Science Foundation of China.

PMID:34590067 | PMCMC8429967 | DOI:10.1016/j.lanwpc.2021.100267

小牡丹

这些孕妇99%以上是90后。6.17%的乙肝感染率，与几十年前没有疫苗的时代区别不大。卫生部的老爷捞钱不少，干人事不多。