慢性乙型肝炎感染的肝臟炎症和晚期肝纖維化血液參數比率

StephenW

Predictive Performances of Blood Parameter Ratios for Liver Inflammation and Advanced Liver Fibrosis in Chronic Hepatitis B Infection
Rongrong Ding  1 , Xinlan Zhou  1 , Dan Huang  1 , Yanbing Wang  1 , Xiufen Li  1 , Li Yan  1 , Wei Lu  1 , Zongguo Yang  2 , Zhanqing Zhang  1
Affiliations
Affiliations

    1
    Department of Hepatobiliary Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
    2
    Department of Integrative Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

    PMID: 33937406 PMCID: PMC8055419 DOI: 10.1155/2021/6644855

Abstract

Objective: Blood parameter ratios, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), have been reported that they are correlated to the progression of liver disease. This study is aimed at evaluating the predictive value of PLR, NLR, and MLR for liver inflammation and fibrosis in patients with chronic hepatitis B (CHB).

Methods: We recruited 457 patients with CHB who underwent a liver biopsy and routine laboratory tests. Liver histology was assessed according to the Scheuer scoring system. The predictive accuracy for liver inflammation and fibrosis was assessed by receiver operating characteristics (ROC) analysis.

Results: PLR and NLR presented significantly reverse correlation to liver inflammation and fibrosis. However, these correlations were not observed for MLR and liver histology. The AUROCs of PLR for assessing G2-3 and G3 were 0.676 and 0.705 with cutoffs 74.27 and 68.75, respectively. The AUROCs of NLR in predicting inflammatory scores G2-3 and G3 were 0.616 and 0.569 with cutoffs 1.36 and 1.85, respectively. The AUROCs of PLR for evaluating fibrosis stages S3-4 and S4 were 0.723 and 0.757 with cutoffs 79.67 and 74.27, respectively. The AUROCs of NLR for evaluating fibrosis stages S3-4 and S4 were 0.590 with cutoff 1.14.

Conclusion: Although PLR has similar predictive power of progressive liver fibrosis compared with APRI, FIB-4, and GPR in CHB patients, it has the advantage of less cost and easy application with the potential to be widely used in clinical practice.

Copyright © 2021 Rongrong Ding et al.

StephenW

慢性乙型肝炎感染的肝臟炎症和晚期肝纖維化血液參數比率的預測性能
丁榮榮1，周欣蘭1，黃丹1，王艷冰1，李秀芬1，李艷1，韋路1，楊宗國2，張占清1
隸屬關係
隸屬關係

    1個
    復旦大學上海公共衛生臨床中心肝膽內科，上海201508
    2個
    復旦大學上海公共衛生臨床中心中西醫結合系，上海201508

    PMID：33937406 PMCID：PMC8055419 DOI：10.1155 / 2021/6644855

抽象的

目的：血液參數比率，包括中性粒細胞與淋巴細胞比率（NLR），血小板與淋巴細胞比率（PLR）以及單核細胞與淋巴細胞比率（MLR），已被報告與肝臟疾病的進展相關。這項研究旨在評估PLR，NLR和MLR對慢性乙型肝炎（CHB）患者肝臟炎症和纖維化的預測價值。

方法：我們招募了457例CHB患者，他們接受了肝活檢和常規實驗室檢查。肝組織學根據Scheuer評分系統進行評估。通過接受者操作特徵（ROC）分析評估了肝臟炎症和纖維化的預測準確性。

結果：PLR和NLR與肝臟炎症和纖維化呈顯著逆相關。但是，MLR和肝組織學沒有觀察到這些相關性。用於評估G2-3和G3的PLR的AUROC為0.676和0.705，分別為74.27和68.75。預測炎症評分G2-3和G3的NLR的AUROCs分別為0.616和0.569，截斷值分別為1.36和1.85。用於評估纖維化分期S3-4和S4的PLR的AUROCs分別為0.723和0.757，分別為79.67和74.27。用於評估纖維化分期S3-4和S4的NLR的AUROC為0.590，截止值為1.14。

結論：儘管CHR患者中PLR與APRI，FIB-4和GPR相比具有進行性肝纖維化的預測能力，但它具有成本低廉，易於應用的優點，有可能在臨床實踐中得到廣泛應用。

版權所有©2021丁榮榮等。

StephenW

https://downloads.hindawi.com/journals/bmri/2021/6644855.pdf